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Health News Archive 583 - Cholesterol
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Blueberry as Effective as Drug in Lowering Cholesterol

Can blueberry skins be a key to controlling cholesterol? Perhaps, according to Agricultural Research Service (ARS) study results announced at the American Chemical Society's March 2007 national meeting in Chicago.

ARS chemist Agnes Rimando and collaborators found that feeding hamsters a diet extremely high in cholesterol, but supplemented with freeze-dried skins of rabbiteye blueberries, produced plasma total cholesterol levels 37 percent lower than those of hamsters fed a control diet.

Levels of LDL—or "bad"—cholesterol were 19 percent lower in the blueberry-supplemented hamsters.

In addition, Rimando, in the ARS Natural Products Utilization Research Unit at Oxford, Miss., found that hamsters eating the blueberry-enhanced food fared better than hamsters fed the high-cholesterol diet augmented instead with the lipid-lowering drug ciprofibrate. Animals in that group exhibited 17 percent less total cholesterol—and two percent less LDL cholesterol—than the control group.

The results may be linked to constituents in blueberry skins that can activate a protein involved in the breakdown and import of fats, according to Rimando. Among these constituents are resveratrol and pterostilbene, which have been cited for their antioxidant properties.

Her main collaborator in the study was chemist Wallace H. Yokoyama of the ARS Processed Foods Research Unit in Albany, Calif. The researchers used 10 hamsters per treatment group, as well as a control diet containing the high amounts of cholesterol, but no supplements.

Supplemented diets consisted of either 7.6 percent blueberry skins or 25 milligrams of ciprofibrate per kilogram of diet.

Reprinted with exclusive permission of ARS, the U.S. Department of Agriculture's chief scientific research agency.

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