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Soy Benefits PSA Levels Following a diet rich in soyfoods may reduce levels of serum prostate-specific antigen (PSA) without impacting testosterone levels, according to a new pilot study. Researchers from the Cancer Research Center of Hawaii randomized 24 men (average age 58 +/- 7.2 years) to a high-soy (two servings/d) or low-soy (normal) diet for three months; after a one-month washout period, they crossed over to the other treatment for another three months. Dietary compliance was assessed by calendars, dietary recalls and urinary isoflavone excretion; blood samples were analyzed for serum PSA and testosterone. During the high-soy diet, dietary isoflavone intake and urinary isoflavone excretion increased significantly compared to the low-soy diet. A 14-percent decline in serum PSA was seen during the high-soy period, with no changes in testosterone. In addition, compliance with the intervention was high, based on dietary calendars and blood tests, demonstrating the feasibility of the intervention. Source: Eur J Clin Nutr, ePub June 14, 2006; DOI: 10.1038/sj.ejcn.1602473 |
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