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Health News Archive 248 - Cancer
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Conjugated linoleic acid inhibits gastrointestinal cancer peritoneal metastasis

According to recent research published in the International Journal of Cancer, conjugated linoleic acid (CLA) inhibits peritoneal metastasis in human gastrointestinal cancer cells.

"The effect of CLA on peritoneal metastasis was examined by in vitro treatment of cancer cells and mouse peritoneal metastasis models. First, cell growth of MKN28 human gastric cancer cells and Colo320 human colon cancer cells was suppressed by CLA in a dose-dependent manner with an increment in apoptosis."

"CLA significantly inhibited invasion into type IV collagen-coated membrane of MKN28 and Colo320 cells (p<.05). CLA-induced growth inhibition was recovered by the exposure to antisense S-oligodeoxynucleotide for peroxisome proliferator-activated receptor (PPAk)-gamma in both cell lines," wrote H. Kuniyasu and colleagues, Nara Medical University.

"BALB/c nu-nu mice were inoculated with MKN28 and Colo320 cells into their peritoneal cavity, and administrated with CLA intraperitoneally (weekly, 4 times). CLA treatment did not affect food intake or weight gain of mice. CLA treatment significantly decreased metastatic foci of both cells in the peritoneal cavity (p<.005)."

The researchers wrote, "Survival rate in mice inoculated with MKN28 or Colo320 cells was significantly recovered by CLA treatment (p=.0025 and 0.0052, respectively). Protein production in MKN28 and Colo320 cells treated with CLA showed a decrease in epidermal growth factor receptor and transforming growth factor-beta and an increase in Bax."

"These findings suggest that CLA inhibits metastasis of human gastric and colon cancer cells," concluded the authors.

Source: Kuniyasu H. Conjugated linoleic acid inhibits peritoneal metastasis in human gastrointestinal cancer cells. Int J Cancer, 2006;118(3):571-576).