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MSM

Health News Archive 195 - Breast Cancer
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Resveratrol Protects Against Breast Cancer

Researchers report in the International Journal of Cancer that resveratrol, a component of red wine, inhibited the development of mammary tumors in mice and reduced the mean number and size of tumors in the animals.

Past studies have indicated that resveratrol may possess anti-cancer activity on the basis of its in vitro effects on tumor cells and its effects in vivo on rodents transplanted with tumors or treated with carcinogens.

In the current study, the Italian researchers investigated resveratrol’s effects on the development of mammary tumors appearing in an experimental model of mice and breast cancer. Resveratrol supplementation delayed the development of spontaneous mammary tumors, reduced the mean number and size of mammary tumors and diminished the number of lung metastases in the mice.

The researchers noted that resveratrol’s mechanism of action may be a result of its ability to downregulate the expression of a gene associated with breast cancer. Resveratrol also increased apoptosis in the cancer cells.

Reference: Provinciali M, Re F, Donnini A, Orlando F, Bartozzi B, Di Stasio G, Smorlesi A. Effect of resveratrol on the development of spontaneous mammary tumors in HER-2/neu transgenic mice. Int J Cancer. 2005 Feb 1.