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Health News Archive 175 - Hyaluronic Acid
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Hyaluronic Acid Absorption and Bioavailability

BioCell Technology LLC, the exclusive suppliers of BioCell Collagen II released results in April 2003 from a double-blind clinical study proving that the naturally occurring Hyaluronic Acid (HA) in BioCell Collagen II has significant peak absorption and steady state bioavailability in normal volunteer subjects.  Dr William Judy, senior scientist at SIBR Research, called the study groundbreaking science and noted BioCell Technology's revolutionary form of a reduced molecular weight HA manufactured using patented technology, is absorbed and is therefore readily available for use by the body. This is in contrast to previous published studies which showed that other HA forms (such as the ones which are injected into joints) are not orally absorbed and thus unavailable for use by the human body.

In a 36-hour peak absorption study using a single dose, BioCell Collagen II hyaluronic acid significantly increased in the blood in four hours and peaked at a level 7008.62% above control in twelve hours (P=0.05). In the blood, HA was rapidly metabolized to two metabolites 1/600th the size of the ingested HA.

In a 28-day steady state bioavailability study using a constant daily dose, after 7 days, BioCell Collagen hyaluronic acid and its metabolites in the blood became stable, and these metabolites remained significantly increased (p=0.001) throughout the balance of the study (HA at 3542.58% above control and HA metabolite at 11890.15% above control).

This unprecedented study on hyaluronic acid, a key element of the unique matrix of BioCell Collagen II which consists of Collagen Type II, Chondroitin Sulfate, and Hyaluronic Acid, demonstrates a synergistic effect that allows for the impressive absorption as indicated in these exciting and promising studies.

By determining the rate and magnitude of HA absorption and its bioavailability, this study using the BioCell Collagen II product clearly demonstrates that this HA form has the physical characteristics necessary to allow it and its metabolites to move rapidly from the blood to the tissues. These findings further support the previous documented efficacy of BioCell Collagen II in the management of joint and skin care.