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Health News Archive 149 - Gum Health
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Vitamin D Levels Linked to Gum Health

Researchers have discovered that Vitamin D may alleviate gingivitis, a condition characterized by inflammation of the gums. Vitamin D has been shown to affect the immune system in vitro and in animal studies. However, data from clinical studies of vitamin D’s effects on inflammatory diseases are scarce.

In the current study, researchers evaluated the association between serum concentrations of 25-hydroxyvitamin D [25(OH)D] (a marker of vitamin D levels) and gum inflammation.

The researchers analyzed data from 6,700 non-smokers ages 13 to 90 years old. The data was drawn from the third National Health and Nutrition Examination Survey. After adjusting for various factors, the researchers determined that compared with subjects who had the lowest vitamin D levels, subjects with the highest vitamin D levels were 20 percent less likely to bleed during probing of the gums.

According to the researchers, “Vitamin D may reduce susceptibility to gingival inflammation through its anti-inflammatory effects. Gingivitis may be a useful clinical model to evaluate the anti-inflammatory effects of vitamin D.”

BACKGROUND: Vitamin D has been shown to have immunomodulatory effects in in vitro and in animal studies. However, data from clinical studies of inflammatory diseases are scarce.

OBJECTIVE: The purpose of this study was to evaluate the association between serum concentrations of 25-hydroxyvitamin D [25(OH)D] and gingival inflammation.

DESIGN: We analyzed data from 77,503 gingival units (teeth) in 6700 never smokers aged 13 to >90 y from the third National Health and Nutrition Examination Survey. Multiple logistic regression models adjusted for subject- and site-specific covariates included age, sex, race-ethnicity, income, body mass index, diabetes, use of oral contraceptives and hormone replacement therapy among women, intake of vitamin C, missing teeth, full crown coverage, presence of calculus, frequency of dental visits, and dental examiner and survey phase. Generalized estimating equations were used to account for correlated observations within subjects.

RESULTS: Compared with sites in subjects in the lowest 25(OH)D quintile, sites in subjects in the highest 25(OH)D quintile were 20% (95% CI: 8%, 31%) less likely to bleed on gingival probing (P for trend < 0.001). The association appeared to be linear over the entire 25(OH)D range, was consistent across racial or ethnic groups, and was similar among men and women as well as among users and nonusers of vitamin and mineral supplements.

CONCLUSIONS: Vitamin D may reduce susceptibility to gingival inflammation through its antiinflammatory effects. Gingivitis may be a useful clinical model to evaluate the antiinflammatory effects of vitamin D.

Reference:

Dietrich T, Nunn M, Dawson-Hughes B, Bischoff-Ferrari HA. Association between serum concentrations of 25-hydroxyvitamin D and gingival inflammation. Am J Clin Nutr. 2005 Sep;82(3):575-80.