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Health News 71 - Skin and Scar Tissue
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• The Effect of Topical Hyaluronic Acid on Wound Healing

The Effect of Topical Hyaluronic Acid on Wound Healing

OBJECTIVE: To observe the effect of topical hyaluronic acid (HA) on wound healing in rats.

METHODS: Forty-eight SD rats were randomly separated into eight groups of 6 rats each. Bilateral dorsal cuts were performed on each rat, left wound was used as the experiment with topical HA and right wound was used as the control only with normal saline. The process of healing was observed histologically following the 1st, 3rd, 5th, 7th, 9th, 14th, 21st, and 28th days postoperatively.

RESULTS: Inflammation was lighter and epidermal healing was faster in cuts treated with topical hyaluronic acid than those in the control. The fibroblasts degenerated and the collagen fiber changed to slim and loose bunches in the hyaluronic acid treated group.

CONCLUSION: The results indicated that topical hyaluronic acid could have powerful infiltrating activity at the early stage of wound healing. HA could accelerate the healing of epidermis and delay the formation of keratinization layer (scar tissue).

Zhonghua Zheng Xing Wai Ke Za Zhi. 2004 Sep;20(5):380-3.
Department of Oral and Maxillofacial Surgery, School of Stomatology, Hebei Medical University, Shijiazhuang 050017, China.

PMID: 15623113

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