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[Benefits | Safety | References]

Helps Maintain Normal Healthy Cholesterol Levels*

The research of gum guggul over the last 30 years has produced a wealth of evidence establishing this herb’s beneficial effect on cholesterol and blood fats. The preliminary studies carried out by Satyavati and her colleagues were done on rabbits fed hydrogenated vegetable oil to artificially elevate cholesterol levels. In contrast to non-treated test subjects, rabbits given gum guggul had normal cholesterol and blood lipid levels and healthy blood vessels.2

A number of multicentric clinical trials have tested the efficacy of Gugulipid® for maintaining normal cholesterol.6 The CDRI has conducted Phase 1 trials to establish the safety of the extract. Gugulipid® has been found safe and free of unwanted effects on blood chemistry, liver function and the heart.7 Phase II trials confirmed Gugulipid®’s effectiveness in normalizing total cholesterol, LDL, HDL and triglycerides.7,8

SOD-Protecting, Antioxidant Action*

In an animal study carried out by the CDRI, guggulsterones reversed the decrease in SOD (superoxide dismutase) activity that results from reduced blood flow to the heart.9 The researchers reported that “SOD was significantly protected by guggulsterone.”9 Increases in lipid peroxides (free-radical byproducts) and xanthine oxidase, an enzyme that produces oxygen free radicals, were also reversed. Although preliminary, these findings lend additional support to the use of Gugulipid® for sustaining cardiovascular health.


Rare instances of rash have been reported. If this occurs, merely discontinue use.

Scientific References

1. Satyavati, G., “Gugulipid®: a promising hypolipidaemic agent from gum guggul (Commiphora wightii).” Economic and Medicinal Plant Research 1991;5:47-82.

2. Satyavati, G., “Gum guggul (Commiphora mukul) — The success story of an ancient insight leading to a modern discovery.” Indian J. Med. Res. 1988;87:327-335.

3. Dev, S., “A modern look at an age-old Ayurvedic drug-guggulu.” Science Age 1987; July:13-18.

4. Atal, C.K., Zutshi, U., Rao, P.G., “Scientific evidence on the role of Ayurvedic herbals on bioavailability of drugs.” J. of Ethnopharmacology 1981;4:229-32.

5. “Bioperine® — Nature’s Bioavailability-Enhancing Thermonutrient. Executive Summary.” 1996; Sabinsa Corporation, Piscataway, N.J.

6. Nityanand, S., Srivastava, J.S., Asthana, O.P., “Clinical trials with Gugulipid®.” J. Ass. Physicians of India 1989; 37(5):323-28.

7. Agarwal, R.C. et. al., “Clinical trial of Gugulipid® — a new hypolipidemic agent of plant origin in primary hyperlipidemia.” Indian J. Med. Res. 1986;84:626-34.

8. “Gugulipid®,” Drugs of the Future 1988;13(7):618-619.

9. Kaul, S., Kapoo, N.K., “Reversal of changes of lipid peroxide, xanthine oxidase and superoxide dismutase by cardio-protective drugs in isoproterenol induced myocardial necrosis in rats.” Ind J. Exp. Biol. 1989; 27:625-27.

Reprinted with exclusive permission of Doctors Best.

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