Calorie Restriction Inhibits, Obesity Fuels Development of 80% of Cancers

A restricted-calorie diet inhibited the development of precancerous growths in a two-step model of skin cancer, reducing the activation of two signaling pathways known to contribute to cancer growth and development.

An obesity-inducing diet, by contrast, activated those pathways, said first author Tricia Moore, a graduate student in M. D. Anderson's Department of Carcinogenesis.

These results, while tested in a mouse model of skin cancer, are broadly applicable to epithelial cancers in other tissues. Epithelial cancers arise in the epithelium - the tissue that lines the surfaces and cavities of the body's organs. They comprise 80 percent of all cancers.

Resveratrol Mimics Calorie Restriction. Read more about calorie restriction and its impact on cancer.

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