Researchers Show Leaky Muscle Cells Lead to Fatigue

The fatigue that marathoners and other extreme athletes feel at the end of a race is caused by a tiny leak inside their muscles that probably also saps the energy from patients with heart failure.

The leak – which allows calcium to continuously leak inside muscle cells – weakens the force produced by the muscle and also turns on a protein-digesting enzyme that damages the muscle fibers. The calcium leak also provides a new explanation for the muscle soreness and fatigue that marathoners and other athletes can experience for weeks after crossing the finish line.

Low dose supplementation with L-carnitine tartrate may reduce muscle damage and boost recovery after exercise.

View further results of this leaky muscle cell fatigue study.

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