Reducing Insulin Signaling in the Brain Can Prolong Lifespan
One route to a long and healthy life may be establishing the right balance in insulin signaling between the brain and the rest of the body.
Studies show that reducing insulin signaling lengthens lifespan. But in humans and rodents, reducing insulin signaling often causes diabetes. “The easiest way to keep insulin levels low in the brain,” White says, “is old-fashioned diet and exercise.”
The study also calls into question the long-term effects of insulin therapy for diabetes, White adds. “High insulin should be the short term solution to insulin resistance, because it might damage the brain in the long run,” he says. Better treatments for diabetes and healthy aging, he suggests, should concentrate on sensitizing the body’s cells to low amounts of insulin.
Read details of this insulin signaling, bran lifespan study.












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