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Hyaluronic Acid Center, Neptune Krill Oil & Rejuvenation Science for Doctors

Monday, July 31, 2006

Mediterranean Diet Better than Low-Fat for Heart Health

Eating a Mediterranean diet with extra nuts or olive oil is significantly better for heart health than a low-fat diet, says a landmark clinical trial from Spain, based upon measurement of body weight, blood pressure, lipid profile, glucose levels, and inflammation measured by c-reactive protein level.

The Mediterranean diet was associated with decreases in plasma glucose levels of 0.30 to 0.39 millimoles per litre. Systolic blood pressure decreased 5.9 to 7.1 mmHg for the Mediteranean diet groups. The ratio of total cholesterol to HDL cholesterol decreased 0.38 to 0.26 for both Med diet groups compared to the low-fat group. The Mediterranean diet with olive oil reduced C-reactive protein levels by 0.54 mg/L compared with the low-fat diet.

View details on this 4 year mediterranean diet low fat diet heart health study.

Omega-3 Fatty Acid Reduce COPD Symptoms

Sixty-four patients with chronic obstructive pulmonary disease (COPD) were randomly assigned to receive 400 kcal/day of a nutritional supplement that was either high or low in omega-3 polyunsaturated fatty acids for two years.

These results indicate that supplementation with a small dose of omega-3 polyunsaturated fatty acids for two years reduced inflammatory markers and improved exercise tolerance in patients with COPD.

View details of this omega-3 chronic obstructive pulmonary disease study.

Saturday, July 29, 2006

2nd Study Confirms Coenzyme Q10 May Stop Migraine Headaches

Coenzyme Q10 can stop migraine attacks in humans, according to a double-blind placebo-controlled study.

Roughly 48 percent of the CoQ10 group experienced a 50% response rate during the three-month study. The patients treated with CoQ10 experienced fewer migraine attacks per month—3.2 after treatment compared to 4.4 before treatment. CoQ10-treated subjects also experienced more headache-free days than the placebo group and fewer days with nausea.

View details and commentary on this Coenzyme Q10 migraine headache study.

Friday, July 28, 2006

Pycnogenol® Pine Tree Bark Reduces Children's ADHD

A study published in the journal of European Child & Adolescent Psychiatry shows a significant reduction of Attention-Deficit/Hyperactivity Disorder (ADHD) symptoms in children after supplementing with Pycnogenol® pine tree bark extract.

After one month of Pycnogenol treatment, the participants’ teachers compared the pre-test results with those scores after one month of treatment with either pine tree bark or placebo. There was a significant drop in hyperactivity and inattention compared to start of the study and placebo.

“These findings are especially notable for parents who are concerned about overmedicating children diagnosed with ADHD. Many families are seeking natural options to avoid the potentially dangerous side effects of prescription drugs,” said Dr. Peter Rohdewald, one of the authors of the study. See FDA Panel Urges Hallucination and Death Warning for Children's ADHD Drugs.

View details of this pycnogenol pine tree bark ADHD study.

Thursday, July 27, 2006

Soda Associated with Weight Gain, Diet Soda is Higher

Researchers collected data on 1,550 Mexican-American and non-Hispanic, white Americans for seven years. About one-third of the 622 participants who began the study with normal weight became overweight or obese.

"What didn't surprise us was that total soft drink use was linked to overweight and obesity," Fowler said. "What was surprising was when we looked at people only drinking diet soft drinks, their risk of obesity was even higher."

View details on this diet soda obesity study.

Wednesday, July 26, 2006

Pycnogenol Pine Tree Bark Decreases Chronic Venous Insufficiency

Research shows Pycnogenol® more effective than Daflon® in reducing leg swelling, walking pain.

Recent findings published in the journal of Clinical and Applied Thrombosis/Hematosis show a significant symptom reduction of chronic venous insufficiency (CVI) in patients after supplementing with Pycnogenol® pine tree bark extract. Published results from this study showed Pycnogenol® to be more effective in reducing edema (leg swelling), tight calves, skin alterations, pain during walking and swelling limbs than Daflon®, a combination of diosmin and hesperidin and a commonly prescribed drug used to treat CVI.

After eight weeks of treatment, patients who supplemented with Pycnogenol® pine tree bark experienced decreased ankle swellings by 35 percent, while Daflon treatment decreased ankle swelling by 19 percent.

View details and commentary on this Pycnogenol pine tree bark chronic venous insufficiency study.

Tuesday, July 25, 2006

Curcumin Reduces Inflammatory Bowel Disease Symptoms

Patients with ulcerative proctitis or proctosignoiditis received 550 mg of curcumin twice a day for one month, and then 550 mg three times a day for one month. All patients improved, with reductions in medication use in four. The improvement in Global score ranged from 15% to 75%.

Patients with Crohn's disease received 360 mg of curcumin three times a day for one month and then 360 mg four times a day for two months. 80% of patients improved, as demonstrated by decreases in Crohn's Disease Activity Index scores of 12.9-44% and reductions in sedimentation rates of 17-71%.

Dr Gaby comments, "The results of the present study suggest that curcumin may also be an effective treatment for inflammatory bowel disease."

View details of this curcumin inflammatory bowel disease study.

Monday, July 24, 2006

Harvard Researchers Find 1000+ IU Vitamin D Healthier

Vitamin D intake above current recommendations may be associated with better health outcomes. This review article summarized evidence from various medical studies regarding concentrations of vitamin D in the blood stream in relation to bone mineral density, dental health, risk of falls, fractures and colorectal cancer.

Researchers at the Harvard School of Public Health say that intake for all adults of at least 1,000 IU of vitamin D daily is needed to bring at least 50% of adult blood serum vitamin D concentrations to healthier levels. Researchers did not speculate on the vitamin D intake required to bring more than 50% of adults to healthier blood levels.

View details of this vitamin D dosage study.

Sunday, July 23, 2006

Soy and Kudzu Phytoestrogens Improve Lipid Profile

Scientists conducting two studies on the lipid activities of soy, and kudzu found phytoestrogens from both plants improved lipid profile, including total cholesterol and certain lipoprotein ratios.

Researchers from The Chinese University of Hong Kong performed separate studies on male and female mice. The female hamsters given phytoestrogens from either soy or kudzu exhibited significantly decreased serum total cholesterol, with no effect on the ratio of HDL to non-HDL cholesterol. In the male mice, soy, but not kudzu, significantly decreased serum total cholesterol, however the kudzu supplementation caused redistribution of cholesterol among lipoproteins, which decreased the ratio of HDL to non-HDL.

Read details on this soy and kudzu phytoestrogen lipid profile study.

Saturday, July 22, 2006

Low Vitamin K Levels Associated with Osteoarthritis

Investigators conducted an analysis of 672 participants in the Framingham Offspring Study. Levels of vitamin K had previously been measured in these participants.

The prevalence ratios for osteoarthritis decreased significantly with increasing plasma vitamin K levels. Researchers concluded that there is an association between low plasma levels of vitamin K and increased prevalence of osteoarthritis manifestations in the hand and knee.

View details of this vitamin K osteoarthritis study.

Friday, July 21, 2006

Researchers Discover Calcium Supplements Effective Only if Taken

Researchers investigated whether or not increased calcium intake, which has been proposed as a population-based public health intervention, could prevent osteoporotic fractures. Nearly 1500 women over the age of 70 participated in this study.

Among the patients, just over 16% sustained one or more fractures. In the overall analysis, calcium supplementation did not significantly reduce fracture risk. However, 830 patients (57%) who took 80% or more of their tablets had reduced fracture incidence in the calcium, compared with the placebo, groups. Researchers concluded that supplementation with calcium carbonate tablets is ineffective as a public health intervention in preventing bone fractures owing to poor long-term compliance, but it is effective in those patients who are compliant.

Comment: We had too much fun developing a title for this study. Alternatives were: 1) Researchers discover 43% of women do not follow directions; 2) Researchers discover 57% of women follow instructions most (80%) of the time; 3) Researchers discover even the cheapest and least absorbable form of calcium is effective for bone strength; or 4) Researchers discover calcium supplements effective only if taken. Wonder how many tax dollars were spent to come to this conclusion. And lastly, sorry we do not carry calcium carbonate. You can probably get it at the 99-cent store.

Read further details on this calcium bone fracture study.

Thursday, July 20, 2006

Omega-3 Fatty Acid Intake Linked with Lower CRP Among Japanese

A report published in the July, 2006 issue of the American Journal of Clinical Nutrition confirmed a correlation between a higher intake of omega-3 fatty acids mainly from fish and a reduction in C-reactive protein (CRP), a marker of inflammation that has been demonstrated to be an independent risk factor for heart attack and stroke.

Subjects whose total intake of omega-3 fatty acids was in the top one-fourth of participants had a 56 percent lower adjusted risk of having a high C-reactive protein level than those whose intake was in the lowest fourth, while those whose EPA and DHA intake was highest had a 46 percent lower risk.The results suggest that even in a population with a relatively high intake, greater omega-3 fatty acid consumption may help reduce serum CRP.

View details of this omega-3 EPA DHA CRP study.


Wednesday, July 19, 2006

Pycnogenol Pine Tree Bark Reduces Leg Cramps 75%

The June 2006 edition of Angiology reported the use of pine tree bark (pycnogenol) in reducing muscle cramps and pain.

In the first part of the study, individuals suffering muscle cramps at least four to eight times weekly and moderate to severe muscular pain at least three days a week were given 50 mg pine tree bark capsules four times daily (for a total dose of 200 mg a day) and were instructed to drink about 1½ quarts of water daily.

By the fourth week of the study, most individuals had a 75% reduction in the amount of muscle cramping.

Read about the second portion of the pycnogenol pine tree bark leg cramp study.


Tuesday, July 18, 2006

Cinnamon Lowers Glucose Levels

Cinnamon extract may positively impact fasting plasma glucose concentrations in Type II diabetics, according to a new study. Researchers enrolled 79 patients with Type II diabetes, who were not on insulin, to take aqueous cinnamon purified extract (3 g/d) or placebo capsules for four months.

At the end of the study, the cinnamon group showed a 10.3% reduction of fasting plasma glucose level, compared to the placebo group. With no adverse reactions reported, the researchers concluded that “cinnamon extract seems to have a moderate effect in reducing fasting plasma glucose concentrations in diabetic patients with poor [blood sugar] control.”

Read details on this cinnamon glucose study.

Monday, July 17, 2006

Folate Supplements Battle Pre-Cancerous Lesions in the Larynx

Folic acid supplements may prevent progression and promote regression of pre-cancerous lesions of the larynx, according to a study in the July 15 2006 issue of Cancer.

43 patients with glottic laryngeal leucoplakia received folic acid (5 mg, three times daily) for six months in a pilot study. At the end of the study period, 31 of the patients had a 50-percent or greater reduction in lesion size; 12 patients showed no evidence of the original lesion.

The researchers concluded: "Folate supplementation, alone or in combination with other chemopreventive drugs, could effectively reduce the risk of progression in an already genetically altered mucosa, especially in patients with hypofolatemia."

View folate pre-cancerous larynx lesion study details.

Sunday, July 16, 2006

Soy Benefits PSA Levels

Following a diet rich in soyfoods may reduce levels of serum prostate-specific antigen (PSA) without impacting testosterone levels.

During the high-soy diet, dietary isoflavone intake and urinary isoflavone excretion increased significantly compared to the low-soy diet. A 14-percent decline in serum PSA was seen during the high-soy period, with no changes in testosterone.

View details of this soy prostate-specific antigen study.

Saturday, July 15, 2006

Treatment of Anal Fissure with L-Arginine Gel

Fifteen patients with chronic anal fissures were studied. The patients applied 1 ml of a gel containing L-arginine (400 mg/ml) to the affected area five times a day for at least 12 weeks. If the fissure persisted, the treatment was continued for a total of 18 weeks. Thirteen patients completed the trial. After 12 weeks, complete healing was seen in eight patients (62%).

Chronic anal fissure has a poor healing rate. The results of the present study indicate that local application of L-arginine promotes healing of anal fissures, even in patients who have failed to respond to isosorbide dinitrate, without causing headache as a side effect.

Read further details of this L-arginine anal fissure study.

Friday, July 14, 2006

Will Statin-Induced Heart Failure be the Next "Vioxx?"

Twenty-one hypercholesterolemic patients who were otherwise healthy received 20 mg/day of simvastatin for six months. The mean left ventricular ejection fraction (LVEF) decreased from 61% at baseline to 58% after one month, but returned to the baseline value at three and six months. The authors concluded that simvastatin treatment is not associated with impairment in left ventricular function in hypercholesterolemic patients after six months of treatment. The study was funded by Merck Sharp and Dohme.

In the new study, the author's conclusion did not mention the significant decrease in LVEF that occurred after one month of simvastatin treatment. This decrease could be clinically significant for patients with heart failure or marginal myocardial function.

One wonders whether statin-induced heart failure will be the next "Vioxx." Perhaps, one day, the main question in a class-action lawsuit will be, what did the drug companies know and when did they know it, regarding the potential of statins to cause heart failure and the ability of coenzyme Q10 to prevent it.

View details and further comments by Alan Gaby MD on this statin research selective reporting.

Thursday, July 13, 2006

Fruit and Vegetable Consumption Linked to Reduced Risk of Cancer

Two new studies have found that fruit and vegetable consumption is linked to a reduced risk of oral cancer and non-Hodgkin's lymphoma.

In the first study, a meta-analysis, researchers determined that for each portion of fruit consumed per day, the risk of oral cancer was reduced by 49 percent. Vegetable consumption also resulted in a 50 percent reduction of oral cancer.

Another study investigated fruit and vegetable intake’s effect on the risk of developing non-Hodgkin's lymphoma (NHL). The results indicated that the more vegetables the subjects consumed weekly, the less their risk of developing NHL.

View details of this fruit and vegetable consumption cancer study.

Wednesday, July 12, 2006

Coenzyme Q10 and Vitamin E Reduces Inflammatory Marker 70%

A combination of the antioxidant nutrients vitamin E and coenzyme Q10 significantly reduced C-reactive protein, a marker of inflammatory status, in adult baboons. Inflammation is recognized as an early process in cardiovascular disease, arthritis, Alzheimer's and cancer.

When C-reactive protein levels were analyzed, vitamin E was found to lower CRP levels to an average of less than half of presupplementation levels. When coenzyme Q10 was added to vitamin E, C-reactive protein levels were reduced to 30 percent of levels measured at the beginning of the study.

The authors called the results “remarkable” given that the animals did not have an inflammatory condition at the time of the study. They conclude that “cosupplementation with vitamin E and coenzyme Q10 significantly enhanced both anti-inflammatory and antioxidant protection. These effects may in turn help protect against vascular diseases.”

View details of this coenzyme Q10 and vitamin E inflammation CRP study.


Pomegranate Slows Progression of Prostate Cancer in Humans

A daily glass of pomegranate juice increased the period of time during which prostate specific antigen (PSA) levels remained stable in prostate cancer patients by a factor of nearly four. Prostate specific antigen is a marker for prostate cancer that is monitored during treatment for the disease, and which should be undetectable after treatment. A rapidly increasing PSA value as ascertained by PSA doubling time indicates cancer progression and an increased risk of death.

In the current study, 50 men treated for prostate cancer with surgery or radiation that subsequently experienced PSA doubling in an average of 15 months were instructed to drink 8 ounces of pomegranate juice per day. Eighty percent of the men experienced a reduction in PSA velocity, with doubling times increasing to an average of 54 months.

View details on this pomegranate juice prostate cancer PSA study.

Monday, July 10, 2006

Olive Extracts Reduce Osteoporosis Bone Loss

The olive polyphenol - oleuropein - reduces bone loss in a rat model of osteoporosis, say French researchers, as science continues to link olive extract with bone health. Oleuropein is currently used in dietary supplements marketed for their benefits for blood pressure and blood glucose levels.

At INRA (Institut National de la Recherche Agronomique), researchers were inspired by epidemiological evidence showing that people who ate a traditional Mediterranean diet were less likely to have osteoporosis. Their early work revealed that both oleuropein and hydroxytyrosol had an impact on inflammation in bones. These findings have since been confirmed in animal studies.

These results appear to show that the polyphenol content of the olives act by reducing inflammation in the rats which worsen the bone loss.

View olive extract osteoporosis bone loss study details.

Sunday, July 09, 2006

Vitamin K Supplementation Increases BMD and Reduces Hip Fracture 80%

Researchers pooled 13 randomized placebo-controlled trials on vitamin K supplementation for bone health. In the seven trials included in this meta analysis which included information on bone fracture rates, it was found that vitamin K supplementation up to 45 mg daily reduced fracture rate between 60% and 81%.

The researchers calculated that the vitamin K supplements were associated with a consistent reduction in all fracture types. Supplementation of vitamin K resulted in reductions in hip fractures of 77 per cent, vertebral fracture of 60 per cent, and all non-vertebral fractures of 81 per cent. The fracture rates were also reduced at all fracture sites, say the researchers, with hip fracture rates reduced by six per cent, vertebral fracture of 13 per cent, and all non-vertebral fractures of nine per cent.

View details of this vitamin K BMD hip fracture study.

Saturday, July 08, 2006

Milk Thistle Protects Against Lung Cancer

A flavanone compound in milk thistle, silibinin, stopped lung cancer growth and spread in mice, says research from the University of Colorado.

After 18 weeks, the silibinin supplemented group had between 32 and 38 per cent less tumors than the urethane-only group, across all the dose range. After 29-weeks, the silibinin supplemented group had between 64 and 70 per cent less tumors than the urethane-only group, across all the dose range. Mice that received the 1.0 per cent silibinin supplement had 93 per cent fewer large tumors than the urethane-only group.

In terms of cancer spread, the tumors in the silibinin supplemented mice had between 41 and 74 per cent fewer cells that tested positive for proliferation (spread) markers. The formation of blood vessels (angiogenesis) was also found to be reduced in the silibinin groups, with reductions up to 89 per cent recorded. “Our most clinically relevant observation was that silibinin prevented tumors from growing beyond a small size in a dose-depended fashion,” said the researchers. “We believe that this inhibition is due, at least in part, to the inhibitory effect of silibinin on angiogenesis.”

View details of this milk extract lung cancer study.

Friday, July 07, 2006

Curcumin Helps Minimize Damage From Smoking and Alcohol Consumption

A new study has found that curcumin, the natural yellow pigment found in turmeric that has been found to help protect against both breast cancer and intestinal cancer.

After two weeks, the researchers found that, compared to the control group: 1. Markers of both liver and kidney damage were “significantly elevated” in the group subjected to ethanol and cigarette smoke but “significantly decreased” in both groups that received curcumin. and 2. HDL and LDL cholesterol levels were: “significantly altered” in the group receiving ethanol alcohol compared to both the control and curcumin groups. HDL levels decreased and LDL levels increased in the groups subjected to ethanol and cigarette smoke.

For the researchers, “curcumin could counteract the injurious effects of combined cigarette smoke and ethanol alcohol and thus might help to reduce the risk which develop due to smoking and drinking.”

View details of this curcumin smoking and alcohol study.

Thursday, July 06, 2006

Cherry Juice Reduces Exercise-Induced Muscle Pain

Drinking cherry juice could reduce the pain and damage in muscles induced by exercise, says a small intervention study from the US. “These results have important practical applications for athletes, as performance after damaging exercise bouts is primarily affected by strength loss and pain,”

The researchers found that the weakening of the elbow flexion strength in the cherry group was significantly lower than the placebo group. The strength loss after four days, tested on an arm curl bench, was only four per cent for the cherry juice group, but was 22 per cent for the placebo group. The development of pain in the muscles, quantified by the volunteers themselves on a scale of zero to ten (zero for no pain, ten for excruciating pain), was also significantly lower for the cherry group (2.4) compared to the placebo group (3.2).

View details of this cherry reduction of exercise-induced muscle pain study.

Wednesday, July 05, 2006

Sytrinol Benefits Diabetes with Improved Insulin Sensitivity

A daily supplement of an extract from citrus peel could reduce insulin resistance in hamsters, suggesting the extract might also help prevent diabetes in humans. “This study provides novel evidence that polymethoxylated flavones (PMFs) in the formulation called Sytrinol reverse hypertriglyceridimia and restores insulin sensitivity,” said researchers.

Because insulin resistance, diabetes, and obesity are recognized as inflammatory disorders, say the researchers, they measured concentrations of the mediators for inflammation, tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6), and markers of immune response, the cytokine IFN-gamma. The researchers found decreased levels of these biomarkers in the Sytrinol PMF supplemented groups and the effect appeared to be dose-dependent.

View details of this Sytrinol diabetes insulin sensitivity study.

Tuesday, July 04, 2006

Folic Acid Supplements Boost DNA Repair, Reducing Cancer Risk

Daily folic acid supplements could improve DNA stability and reduce the risk of certain cancers linked to faults in the genetic code, suggests new research. Folate is a B vitamin found in green and leafy vegetables. It is needed in the body to make and repair DNA. This is important as damage to a cell's DNA can lead to cancer.

The randomized, double-blind, placebo-controlled study was carried out with 61 healthy volunteers, who received 1,200 mcg folic acid or a placebo for 12 weeks. The folic acid dose is significantly lower than the pharmacological doses used in many clinical trials.

“There was a strong correlation between the magnitude of lymphocyte total folate and reduction in lymphocyte DNA uracil misincorporation. Uracil misincorporation is evidently more sensitive to improved folate status in healthy individuals than other putative biomarkers of DNA damage or repair, and may, therefore, be considered a valid and functional biomarker for the influence of folate on genomic stability in health people,” concluded the researchers.

View details on this folic acid DNA cancer risk study.

Monday, July 03, 2006

Omega-3 Rated Better than Ritalin for ADHD

Supplements of omega-3 and omega-6 improved the attention span and hyperactivity scores of young Australians, and was rated better than the common medication Ritalin. The study adds to a growing number of studies looking at the effect of fish oils on the behavior and learning of kids.

“Supplementation with omega-3 and omega-6 PUFA over 15 weeks resulted in significant improvements compared to placebo in parent ratings of core ADHD-related behavioral and cognitive difficulties, namely inattention, hyperactivity and impulsivity,” reported the researchers.

“This study shows once again that omega-3 can have a very beneficial effect for children with concentration and behavior problems. This new study adds to the mounting evidence that nutrition is safer and more effective than stimulant medication,” she said.

View details on this omega-3 Ritalin ADHD comparison study.

Sunday, July 02, 2006

Pinolenic Acid Reduces Desire to Eat by 29%

Pinolenic Acid Induces Satiety-producing Hormone Release in Overweight Human Volunteers.
Numerous food-associated hormones are secreted by enteroendocrine cells of the gastrointestinal tract in response to the macronutrient composition of a meal. These hormones act as circulating ligands in the peripheral and central nervous system and result in behavioral modifications such as food intake reduction. The most well-known of these hormones are cholecystokinin (CCK), and glucagon-like peptide (GLP-1).
The study demonstrated a significant increase in the satiety hormones CCK and GLP-1 over 4 hours after taking pinolenic acid. Subjective appetite scores followed a similarly significant pattern. "Desire to eat" and "prospective food intake" as measured on a visual analog scale (VAS) were 29 and 36% lower than placebo, respectively.

AMA Recommends FDA Revoke Salt's GRAS Status; FDA Increases Allowable Salt in Foods

The American Medical Association recommended that salt should not be "generally recognized as safe" and has urged the Food and Drug Administration to revoke its GRAS status and to develop safe upper limits for sodium in processed and restaurant foods.
According to the AMA, Americans consume an average 4,000 mg of sodium daily, and about 75 percent of that comes from processed foods and foods eaten away from home.
In a related development, the FDA eased salt requirements for healthy foods beginning January 2006. The Food and Drug Administration announced in November 2005 that it would allow higher levels of sodium than it previously had in foods seeking a “healthy” designation. The FDA feared that with a lower salt level in "healthy" processed foods, people would stop eating this processed food. What did the FDA fear, that people looking for healthy food would start eating fresh food?