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Hyaluronic Acid Center, Neptune Krill Oil & Rejuvenation Science for Doctors

Friday, June 30, 2006

Broccoli Compound Prevents Melanoma Metastasis

Sulforaphane significantly prevented the metastasis of melanoma cells in mice. Sulforaphane is an isothiocyanate found in broccoli and other cruciferous vegetables that has been shown to help protect against chemically-induced tumors.
The current study utilized mice in whom melanoma tumor cells were injected. The control mice were found to have a significant amount of lung tumors compared to animals who received sulforaphane. Sulforaphane given simultaneously with the tumor cells was the most effective mode of administration, being associated with an inhibition of 95.5 percent of metastases, and an increase in lifespan of 94 percent compared to the control group.
In-vitro research showed that sulforaphane inhibited the activation of matrix metalloproteinases, which are enzymes that degrade the cell membrane and facilitate the metastasis of tumors. The authors suggest that sulforaphane's antimetastatic activity may be mainly due to this action.

Thursday, June 29, 2006

Anti-Oxidants Reduce Free Radicals, Aging, and Disease

Scientists at Harvard Medical School have found a mechanism behind the damage that oxidative stress causes to cells which results in the deterioration associated with aging and disease. Oxidative stress is caused by highly reactive molecules known as free radicals formed as a byproduct of metabolism. Although free radicals are quenched by antioxidants, the increase in free radical production that occurs with age overwhelms the body's antioxidant defenses, resulting in damage to the cells' DNA, proteins and lipids.
Azad Bonni, MD, PhD and colleagues discovered that exposure of brain neurons to oxidative stress signals caused by free radicals stimulates the activity of an enzyme called MST, which previous research had determined to be involved in cell death.

Wednesday, June 28, 2006

The Asian Paradox

A review by Yale University researchers concluded that green tea consumption may be the explanation of the "Asian paradox." Similar to the French paradox, which refers to the hypothesis that red wine protects the French from the adverse cardiovascular effects of a fatty diet, green tea may protect Asians from the adverse effects of smoking. Many people in Asia are smokers, yet there is a lower incidence of cardiovascular disease and cancer than in many countries in which fewer people smoke.
The average 1.2 liters of green tea consumed each day by many Asians provides the antioxidant epigallocatechin gallate (EGCG), which may reduce low density lipoprotein (LDL) oxidation, lower platelet aggregation, regulate lipids, and promote proliferation and migration of smooth muscle cells, which are all factors involved in reducing cardiovascular disease. Green tea has also been demonstrated to prevent the growth of some tumors.
Read futher observations in this green tea smoker cancer study.

Tuesday, June 27, 2006

Pine Nut Oil Cuts Appetite

Certain fatty acids in pine nuts might help curb appetite, according to a new study. Researchers extracted those fatty acids, called pinolenic acid, from Korean pine nuts, tested the oil, and reported the results in Atlanta at the American Chemical Society's National Meeting & Exposition.
Pine nuts, often used in pesto, are actually seeds, not nuts. Certain fatty acids found in Korean pine nuts can initiate the release of an appetite-suppressing hormone called cholecystokinin (CCK) in lab studies.
The women who had taken the pine nut capsules reported less hunger and showed higher levels of CCK and GLP-1 than those who took the placebo pills.
View details on this pine nut oil appetite study.

Monday, June 26, 2006

Pine Nut Fat - Pinolenic Acid - Stops Overeating

A fatty acid extracted from pine nuts can suppress appetite and reduce the amount of food people feel like eating, according to Dutch firm Lipid Nutrition, introducing the new weight management ingredient pinolenic acid to the food and supplement industry.
One of few companies to introduce a novel ingredient at Vitafoods this week, Lipid Nutrition will be hoping to gain a significant edge in the competitive weight loss sector by offering more than one solution to obesity. It also markets the fat loss ingredient CLA (conjugated linoleic acid), which reduces weight through a different mechanism. The firm extracts the long-chain polyunsaturated fatty acid pinolenic acid from the seeds of the Korean pine nut tree (Pinus koraiensis), one of more than 140 varieties of the nut, which also grows in China.
One of the main advantages of the ingredient is its safety profile. “There is a history of pine nut consumption so we could do the human study quite rapidly,” said Dr Einerhand.
Read further details about the new product pinolenic acid.

Sunday, June 25, 2006

Pycnogenol Pine Tree Bark Helps Treat Migraines

Alternative migraine therapies in the form of butterbur extract, coenzyme Q10, melatonin, and glucosamine have been found effective for some people. Current drug treatment includes five groups of medications: beta-blockers, calcium channel blockers, tricyclic antidepressants, anticonvulsants, and nonsteroidal anti-inflammatory drugs.

Now a new study has found that pine tree bark pycnogenol may provide an alternative treatment for migraines in adults.

Not only did the researchers find “a significant improvement” in the MIDAS score, there were also “significant reductions” in both the number of headache days and headache severity. Specifically, the average number of headache days was reduced from 44.4 days at the beginning of the study to 26 days at the end of the study. Headache severity was reduced by nearly 27%.
The researchers concluded “antioxidant therapy…may be beneficial in the treatment of migraine possibly reducing headache frequency and severity.”

Saturday, June 24, 2006

D-Ribose as Adjunctive Therapy for Congestive Heart Failure

In a study presented to the Heart Failure Society of America in Boca Raton, Florida, D-ribose, a natural occurring pentose carbohydrate, has repeatedly shown to enhance high energy phosphates and improve diastolic dysfunction following myocardial ischemia.
A two-center study investigated the effect of Ribose on ventilatory efficiency in CHF patients (NYHA Classes II-IV). D-ribose significantly improved ventilatory efficiency in patient Classes III and IV, with a trend towards improvement in Class II patients. Oxygen uptake efficiency demonstrated a strong trend in Classes III and IV.

"These patients demonstrated improved heart function and an increased ability to utilize oxygen," said Nampalli Vijay, MD, one of the leaders of the study. "We believe D-Ribose should be considered as an adjunctive therapy for all Class III and IV CHF patients."

Friday, June 23, 2006

Pinolenic Acid Reduces Desire to Eat by 29%

Obesity and overweight are conditions that affect over half of the US population. Numerous treatment options are available to help combat weight gain, including reduction of food intake by appetite suppression.
Pinolenic acid induces satiety-producing hormone release in overweight human volunteers. The Korean pine nut contains significant levels of certain fatty acids, called pinolenic acid, shown in vitro to induce the release of CCK in STC-1 enteroendocrine cells.
The study demonstrated a significant increase in the satiety hormones CCK and GLP-1 over 4 hours.
View details of this pinolenic acid satiety study.

Thursday, June 22, 2006

D-Ribose Improves Ventilatory Efficiency in Congestive Heart Failure Patients

Ventilatory efficiency is recognized as an important predictor of survival and disease progression among patients with congestive heart failure (CHF). Thus, improving ventilatory efficiency in this population is of prime importance. A research report presented at the American College of Cardiology's Annual Scientific Session, suggests that D-Ribose can play a significant role in this key pursuit.
"This study showed a real benefit in ventilatory parameters during cardiopulmonary exercise testing. A significant improvement was noted in ventilatory efficiency, oxygen uptake efficiency, and myocardial performance in class II and III heart failure patients."

Wednesday, June 21, 2006

Heart Attack Patients Undergoing Bypass Surgery Improve with D-Ribose

Performing cardiopulmonary bypass surgery without the use of a heart-lung machine on patients with acute myocardial infarction has gained acceptance in recent years. Research shows that treating patients with D-Ribose prior to off-pump cardiac revascularization can improve post-operative cardiac function.
The patients treated with D-Ribose showed a 49% greater increase in cardiac indices after surgery. Said Dr. Perkowski, "This study shows that ribose can improve the outcome for many patients facing revascularization, and that more patients may qualify for an 'off-pump' procedure."

Tuesday, June 20, 2006

Vitamin Deficiency Causes Brainstem and Spinal Injury

Vanderbilt University researchers reported a short period of combined vitamin E and C deficiency caused profound central nervous system (CNS) dysfunction in guinea pigs.
Upon serial sectioning of the pigs' brains and spinal cords, only the pigs in the doubly deficient group showed central nervous system damage, primarily nerve cell death, axonal degeneration, vascular injury and associated glial cell (non-neuronal brain cell) responses. Most severely affected were the ventral pons (section of the brainstem under the cerebellum) and the brainstem, which often exhibited asymmetric cystic lesions. According to researchers, several aspects of these lesions suggest that the primary damage occurred in the blood vessels. They concluded the results indicate paralysis and death in guinea pigs linked to a combined vitamin E and C deficiency is caused by severe damage to the brainstem and spinal cord.

Monday, June 19, 2006

Colostrum Boosts Mucosal Immunity in Athletes

Taking bovine colostrum may inhibit upper respiratory tract infections (URTI), according to a clinical trial from Massey University in Auckland, New Zealand.
Median levels of secretory-IgA increased by 79 percent in the colostrum group after 12 weeks of supplementation. The researchers concluded colostrum supplementation increased s-IgA levels among a cohort of athletes.

Resveratrol Protects Against Neuronal Damage

Resveratrol may have neuroprotective effects, according to a study published in the Journal of Agricultural and Food Chemistry.
In rats not administered resveratrol, hydroxyl radical levels were elevated and severe neuronal loss occurred in the brain. In contrast, brains of animals given resveratrol had significantly increased concentrations of nitric oxide (NO) and decreased population of hydroxyl radicals. Rats given resveratrol were also shielded from reduced cerebral blood flow and neuronal loss.
The researchers concluded a single dose of resveratrol could produce neuroprotective effects

Saturday, June 17, 2006

Pomegranate Inhibits Lung and Prostate Cancer

Pomegranate may have chemopreventive effects against lung and prostate carcinomas, according to abstracts of two studies presented at the 97th Annual meeting of the American Association for Cancer Research (AACR) in April.
As the leading cancer killer in men and women, lung cancer affects an estimated 350,000 Americans and causes more deaths than the next three most common cancers combined (colon, breast and prostate). While the 5-year survival rate for colon, breast, and prostate cancer patients is 63%, 88%, and 99%, respectively, it is only 15% for lung cancer patients.
Following up on research showing pomegranates to have "remarkable anti-tumor promoting effects" in mouse skin and prostate cancer, researchers treated human lung cancer cells for three days. Although pomegranate extract did not induce cancer cell death, it prevented further cancer cell division by stopping activity of a number of proteins that are active during cancer.

Friday, June 16, 2006

Omega-3 DHA Reduces Bone Loss

Researchers from Purdue University and Indiana University have found high intake of omega-3 fatty acid DHA inhibited bone loss in an animal model of postmenopausal osteoporosis. Because low estrogen levels are thought to play a role in bone loss, researchers evaluated the effects of the ratio of dietary omega-6 and omega-3 fatty acids on bone mineral density in rats without ovaries.
Researchers wrote, “This study indicates that the dietary ratio of n-6/n-3 [omega-6/omega-3] PUFAs and bone tissue concentration of total long-chain n-3 [omega-3] PUFAs (DHA) minimize femur bone loss as evidenced by a higher bone mineral content in ovarectomized rats.”
View details on this omega-3 DHA bone loss study.

Thursday, June 15, 2006

Omega-3, Quercetrin Combo Eases Bowel Inflammation

A combination of omega-3 fatty acids and the flavonoid quercitrin may work to reduce inflammation in the large intestine associated with Crohn’s disease and ulcerative colitis, says an animal study from Spain.

“We demonstrated in a rat model of experimental colitis that the incorporation of a low amount of fish oil in the diet, enough to change the omega-6 to omega-3 ratio both in the rat diet and in different tissues, was able to exert an intestinal anti-inflammatory effect,” wrote the researchers. The benefits of this is due to a synergetic mechanism between the quercitrin, which can inhibit colonic TNF-alpha and IL 1-beta production, as well as acting as an antioxidant, and the fish oils which inhibit TNF-alpha and LTB4 production.

Read details on this omega-3 quercetrin bowel inflammation study.

Wednesday, June 14, 2006

Oral Contraceptive Causes Depletion of CoQ10 and Vitamin E

Women taking oral contraceptives have lower levels of coenzyme Q10 and vitamin E, and could possibly benefit from supplements, suggests a new study. “. . . women who receive oral contraceptives may be considered for coenzyme Q10 and/or alpha-tocopherol supplementation,” wrote researchers from the Albert Einstein College of Medicine in New York.

Coenzyme Q10 and alpha-tocopherol (a form of vitamin E) are capable of mopping up free radicals that can lead to oxidative stress. Coenzyme Q10 enables cellular energy production in the mitochondria. A lack of both these nutrients is linked to a variety of disease including Alzheimer's, cardiovascular disease and cancer.

“The results clearly show that the use of oral contraceptives significantly lowered the serum levels of coenzyme Q10 and alpha-tocopherol, compared with levels in non-oral contraceptive users,” wrote the researchers.

View details on this oral contraceptive CoQ10 vitamin E depletion study.

Tuesday, June 13, 2006

Human Intestine Contains 100 Trillion Bacteria

Inside each of us is a vast ecosystem, as complex as the soil or the oceans, that helps us digest food and contributes to our health and well-being. Gene experts after studying the DNA of hundreds of different kinds of bacteria in the human intestines have reached the conclusion that the human race survives, even thrives, with the help of millions of bacteria within our bodies.

Scientists from the Institute for Genomic Research in Maryland say that because bacteria are so important to key functions such as digestion and the immune system that we may be in fact be symbiotic organisms - relying on one another for life itself. This microbial population is what dictates our well-being and any change or shift within this population which may lead to the absence or presence of beneficial microbes, can trigger defects in metabolism and the development of diseases such as inflammatory bowel disease.

Read more about this human intestinal bacteria study.

Monday, June 12, 2006

Workouts Reduce Abdominal Fat

In a study, it took only 15 weeks of twice-a-week workouts -- no dieting -- for a group of women to significantly reduce the fat around their middles and add lean muscle.

Both are good steps if you're trying to improve your overall health (not to mention button your jeans). But in relation to breast cancer and colon cancer, the weight work also favorably changed two other potential troublemakers: glucose levels and a growth factor called IGF-I that may encourage the development of tumors.

And that's not all squats, curls, and bench presses can do. Follow-up research has found that strength training fights the weight gain that often plagues women who have fought -- and won -- the battle against breast cancer. There's hope that keeping the pounds down may help stave off a recurrence down the road.

View details of this workout abdominal fat study.

Sunday, June 11, 2006

Probiotics Reduce Risk of Liver Cancer

A daily probiotic supplement could reduce the risk of liver cancer caused by fungal toxins in foods, a leading cause of the disease.

The double-blind, placebo-controlled trial with two parallel groups randomly assigned the volunteers to either the intervention group – two probiotic capsules per day containing a mixture of the strains Lactobacillus and Propionibacterium, or placebo.

“Probiotic administration led to a statistically significant decrease in the level of urinary excretion of AFB-N7-guanine. The reduction was 36 per cent at week three and 55 per cent at week five,” wrote lead author Hani El-Nezami. The reduction in excretion levels of the aflotoxin metabolite indicates that the concentration within the body of carcinogens was decreasing.

View details on this probiotic liver cancer study.

Saturday, June 10, 2006

Homocysteine Levels Associated with Coronary Artery Disease

In an article published in the American Journal of Geriatric Cardiology, 172 elderly individuals underwent coronary angiography to investigate the influence of age and coronary artery disease on homocysteine levels.

It was found that for each mmol per liter increase in homocysteine level there was a 7% increase in risk of coronary artery disease. Hyper-homocysteinemia were said to constitute an independent risk factor for coronary artery disease with a risk ratio of over 100%. There was a relative progression of homocysteine levels between the young old and the oldest old.

Read details of this homocysteine coronary artery disease study.

Friday, June 09, 2006

Acetyl L-Carnitine Treats Neuropathy Induced by HIV Medications

Twenty-one HIV-infected patients with toxic neuropathy induced by antiretroviral drugs received 1,500 mg of acetyl L-carnitine (ALC) twice a day for a median duration of 14 months.

After six months of treatment, histological evidence of nerve regeneration was seen; these improvements continued or stabilized after 24 months of treatment. The neuropathy improved in 76% of the patients and remained stable in an additional 19%.

View details and commentary on this Acetyl L-Carnitine Neuropathy by HIV medication study.

Thursday, June 08, 2006

Blueberries Strengthen Blood Vessels

Blueberries could strengthen blood vessels against oxidative stress that may lead to heart disease, says new research. Scientists investigated the effects of blueberries on functional and structural molecules in the walls of rat aortas.

Over a 13-week period a control group was fed a standard diet, while an intervention group received the standard diet supplemented with eight per cent powdered wild blueberry.

“In this study we document for the first time that diets enriched with wild blueberries significantly alter the composition and structure of rat aorta at the glycosaminoglycan level,” wrote researchers.

View details on this blueberry blood vessel study.

Wednesday, June 07, 2006

Blueberries Stop Liver Cancer Growth

Scientists report that blueberry extracts inhibited the growth of liver cancer cells.

Blueberries, nature's only ‘blue' food, are a rich source of polyphenols, potent antioxidants that include phenolics acids, tannins, flavonols and anthocyanins. Researchers have also revealed that a compound found in blueberries called pterostilbene, similar to resveratrol, could be as effective as a widely used synthetic drug in reducing cholesterol.

Scientists tested the inhibition of the blueberry extracts on liver cancer cell growth. The extract concentration under which 50 per cent of the cancer cell population growth was inhibited, IC50, was used as a comparative measure. Various blueberry cultivars achieved IC50 at was 140 micrograms of anthocyanins per milliliter of solution, 165, and 200 micrograms per millilitre.

View details on this blueberry liver cancer cell growth study.

Tuesday, June 06, 2006

Vitamin K from Natto Reduces Bone Loss 80%

Natto, the traditional Japanese fermented soybean and a rich source of vitamin K2, could reduce bone loss in post-menopausal women by as much as 80 per cent, says research from Japan.

There is a growing body of science linking vitamin K to benefiting bone health as it influences the secondary modification of osteocalcin, a protein needed to bind calcium to the bone matrix.

The protective effects also appeared to increase with increasing age. For example, post-menopausal women in their fifties eating more than four packs of natto per week had a bone mineral density (BMD) loss in the femoral neck of one per cent per year, compared to 1.6 per cent per year for the same age and a natto-free diet. Women in their seventies had bone mineral density losses of 0.5 per cent per year when consuming more than four packs per week, while septuagenarians consuming a natto-free diet had average BMD losses of 1.8 per cent per year.

View details on this vitamin K natto bone loss study.

Monday, June 05, 2006

Acai Fights Leukemia Cells

Acai, one of the latest, hot new health food discoveries from the Amazon rainforest boasts some impressive credentials as a source of omega-6 and omega-9 fatty acids, vitamins A, C and E and more than 50 other antioxidants, especially anthocyanin—the powerhouse pigment found in red wine and blueberries.

The study tested the effect of pure acai juice on HL-60 human leukemia cells in vitro. They found that the extracts “reduce cell proliferation from 56% to 86%, most likely by damaging the cells enough to cause them to self-destruct.

Read details on this acai leukemia cell study.

Sunday, June 04, 2006

Omega-6 Rich Margarine Linked to Adult Asthma

A high intake of margarine has recently been linked to an increased risk of asthma in adults. Some researchers think that the omega-6 polyunsaturated fat from vegetable oil in margarine may play a role, as eating lots of it can boost inflammation throughout the body, including the lungs.

A high intake of oleic acid was positively associated with asthma while no significant associations were found for the other dietary fatty acids. Most prominently, a high margarine intake increased the risk of onset of asthma in adulthood

Balancing the intake of pro-inflammatory omega-6 fatty acids with reduction and with addition of anti-inflammatory omega-3 fatty acids from fish oil may offset the negative effects. Also see the study: Omega-3 Fatty Acids May Help Prevent Asthma.

View details on this omega-6 margarine adult asthma study.

Saturday, June 03, 2006

Probiotic Reduces IBS Symptoms in 88% of Patients

Institut Rosell reported a new clinical study showing that Lacidofil, its proprietary probiotic formulation, reduced the symptoms associated with chronic Irritable Bowel Syndrome (IBS).

The study involved 50 patients with at least a 10-year history of chronic IBS. Eighty-eight percent of the patients experienced a reduction of IBS-related complaints, and most of them voluntarily continued to take the probiotic several months after completion of the study. No side effects were reported.

Read details on this probiotic IBS study.

Thursday, June 01, 2006

Curcumin More Effective than Drugs for Alzheimer's

Curcumin, from tumeric, is the yellow pigment in curry spice. It was found it to be more effective in mice than drugs currently being investigated for Alzheimer's disease treatment.

Reporting in the December 2004 online edition of the Journal of Biological Chemistry, researchers from the University of California Los Angeles also revealed that curcumin is more effective in inhibiting formation of the protein fragments than many other drugs being tested as Alzheimer's treatments.

The researchers found the low molecular weight and polar structure of curcumin allow it to penetrate the blood-brain barrier effectively and bind to beta amyloid (which form the Alzheimer's disease-causing plaques).

View details on this curcumin turmeric Alzheimer's study.