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Hyaluronic Acid Center, Neptune Krill Oil & Rejuvenation Science for Doctors

Wednesday, May 31, 2006

Omega-3 Fatty Acids Help Protect Against Retinal Degeneration

The role that omega-3 fatty acids in fish oil plays in protecting cells in the retina from degenerative diseases like retinitis pigmentosa and age-related macular degeneration, the leading cause of loss of vision in those older than 65.

DHA, known to be in short supply in patients with retinitis pigmentosa and Usher's syndrome, promotes protective cell signaling by facilitating the expression of helpful rather than destructive proteins as well as stimulating the production of NPD1. DHA and NPD1 also decrease the production of damaging free radicals. DHA has been shown by Dr. Bazan to promote survival and inhibit cell death not only of photoreceptor cells, but also of neurons in an experimental model of Alzheimer's disease.

Read more about this omega-3 fatty acid retinal disease (AMD) study.

Tuesday, May 30, 2006

CLA Causes Abdominal Fat Loss

Lipid Nutrition is announcing the findings of a new human trial using CLA, that reinforces the fatty acid's fat mass reduction claim and shed light on the main locations of fat reduction – especially for the upper leg and abdomen areas.

At the end of six months, CLA's effect on fat mass was seen to be a decrease of around 4.4 pounds compared to placebo. Lean body mass was seen to increase by an average of 1 pound in the CLA group, over the placebo group

The area in which the study really shed light is the location of fat mass reduction – seen to be focused on the abdomen and the legs. This gives credence to CLA's promotional claims to be a body shaper.

View details of this CLA abdominal body fat loss study.

Monday, May 29, 2006

L-Carnitine and Alpha Lipoic Acid Reduce Ageing and Boost Energy

A combination of two common dietary supplements, L-carnitine and alpha-lipoic acid, could reduce oxidative stress associated with ageing and boost energy production, says new research.

Researchers gave L-carnitine and alpha-lipoic acid separately or together to young, middle aged, and older rats. Researchers found that the concentration of free radicals in mitochondria, energy-producing organelles in their cells, were lower than when used independently or not at all.

“Our study strongly suggests that supplementation of mitochondrial metabolites, carnitine and lipoic acid may prevent mitochondrial damage and restore mitochondrial function during ageing process,” said the researchers. “Alpha-lipoic acid protects mitochondria by removing free radicals and improves the recycling of other antioxidants. Carnitine is more potent in restoring mitochondrial energy production. Thus the combination is complementary,” they concluded.

View details of this alpha lipoic acid l-carnitine aging and energy study.

Sunday, May 28, 2006

Padma Basic Effective for Improving Peripheral Arterial Disease

A meta-analysis of 19 published clinical trials on Padma Basic®, a Tibetan herbal formula, has concluded that the preparation is safe and effective in providing significant relief for a common vascular condition - peripheral arterial disease (PAD).

Current FDA approved drugs have shown some limited benefit to treating peripheral arterial disease, but often the side effects of these drugs make such treatment undesirable. In contrast, this recent meta-analysis of clinical trials with Padma Basic® indicates that this Tibetan herbal formula supports healthy circulation without side effects and with the similar results to standard medications.

View details on this Padma Basic peripheral arterial disease study.

Saturday, May 27, 2006

Pine Tree Bark Extract Reduces Inflammation

A study published in the Journal of Inflammation showed the effectiveness of pine bark extract Pycnogenol in preventing harmful inflammation induced by immune system response.

The clinical study showed that a 200 mg daily oral intake of maritime pine tree bark extract lowered the activity of nuclear factor-kappa B (NF-kB), the immune cell ‘trigger’ for inflammation, in a group of seven healthy volunteers.

Results of a study to be released later this year showed Pycnogenol reduced inflammation relating to symptoms of knee osteoarthritis.

View more information on this initial pine tree bark extract inflammation study.

Friday, May 26, 2006

Cardiothoracic Surgeon Reports Zero Percent Mortality with Ribose

Pioneering Beating Heart CABG MD Presents ATS Paper on Using Ribose to Rebuild the Energy Supply of the Heart Prior to Bypass Surgery.

Even though he has performed the highest percentage of Beating Heart Coronary Artery Bypass Grafting (also called Off Pump CABG) procedures of any doctor in the U.S. since 1990, Dr. David Perkowski was still looking for improvement. Treating his patients with D-Ribose (CORvalen™) before surgery proved to be just what the doctor ordered.

"In the ribose group we saw a post-operative improvement in cardiac index that was 55-percent higher than the non-treated group, which is quite astounding." An improved cardiac index means the heart is able to pump more blood to the body with each heartbeat. With the ribose supplementation the heart can recruit energy more effectively helping it to simply pump better.

"It's hard to believe it can be so effective, so quickly, but we've got the data to prove it." There is one other number Dr. Perkowski hasn't yet discussed, and it's a significant one. "Our predicted mortality rate with the ribose patients was between four-and-a-half to five percent. Our actual mortality rate with the ribose patients is zero. We think that is extremely important, particularly given the fact the patients we see belong to the oldest and highest risk group."

Read details on this ribose cardiac surgery paper.

Thursday, May 25, 2006

Garlic Compounds Stop Liver Cancer Growth

Several compounds from garlic have been reported to have anti-cancer activity, including allicin, the substance that gives garlic its distinctive aroma and flavor, and its derivative, diallyl disulfide (DADS). However, both have been shown to kill not only cancer cells, but also healthy human body cells.

The garlic extracts, said the researchers, “showed a dose- and time-dependent effect on cell proliferation, with a significant reduction of viable cell number at 24 hours with a less pronounced recovery of cell proliferation at 48 hours.”

View details on this garlic liver cancer study.

Wednesday, May 24, 2006

Ginseng Associated with Reduced Death and Increased Quality of Life in Breast Cancer Patients

Breast cancer patients who consume ginseng experience a reduced death rate from breast cancer and have an improved quality of life, according to an epidemiological study in China.

Compared with breast cancer patients who never used ginseng, regular users had a significantly reduced risk of death. Ginseng consumers were 30 percent more likely to survive the illness compared to non-users. In addition, ginseng use after cancer diagnosis, particularly current use, was positively associated with quality of life scores. Additionally, quality of life improved as cumulative ginseng use increased.

Read details of the ginseng breast cancer study.

Tuesday, May 23, 2006

Breakthrough Cholesterol Control from Krill Oil

Neptune Technologies has announced results from a clinical trial that reports a daily dose of its neptune krill oil can lower bad LDL cholesterol levels by 34 per cent and boost good HDL cholesterol by 44 per cent. And when Neptune Krill Oil (NKO) was used in combination with low-dose statins, the effects were even more pronounced.

The double-blind, randomized clinical trial compared the effects of Neptune Krill Oil, fish oil, or placebo, with or without statins - a total of six experimental groups. After 90 days of usage, the researchers found that Neptune Krill Oil alone lowered LDL-cholesterol by 34 percent, and increase HDL cholesterol levels by 43.5 percent.

View details of this cholesterol lipid neptune krill oil study.

Monday, May 22, 2006

Avemar Acknowledged by Memorial Sloan-Kettering Cancer Center

The Memorial Sloan-Kettering Cancer Center in New York has published an article on Avemar on their website.

Avemar fermented wheat germ extract was developed by Mate Hidvegi, a Hungarian chemist, in the 1990s. Avemar is used as a dietary supplement by cancer patients in Hungary to improve quality of life. Memorial Sloan-Kettering continues their article to describe Avemar research, uses, mechanism of action, warnings, contraindications, adverse interactions, drug interactions, literature summary and critique.

View more Avemar information from Memorial Sloan-Kettering Cancer Center and a link to their website review.

Sunday, May 21, 2006

Cinnamon Lowers Blood Pressure and Improves Insulin Function

For the first time, cinnamon has been shown to lower the systolic blood pressure of spontaneously hypersensitive rats. The results also add to a growing body of research demonstrating cinnamon’s role in managing blood sugar levels and improving insulin function.

“Research on cinnamon has pointed to its efficacy in maintaining favorable blood glucose levels and reducing serum cholesterol in people with type 2 diabetes,” said lead researcher Dr. Richard Anderson from the USDA. “This is the first time we have seen the positive effects of cinnamon on blood pressure levels, a common co-factor to diabetes and one of the risk factors associated with cardiovascular disease.”

View details of this cinnamon blood pressure insulin function study.

Saturday, May 20, 2006

Melatonin as Effective as Sleep Medication

In the double-blind placebo-controlled study, 36 healthy individuals were forced off their normal sleep schedules.

The individuals on melatonin had significantly improved sleep efficiency and got 30 minutes more sleep per sleep cycle, on average, than the controls. Researchers note that while that may not sound like much, it is approximately the same as individuals on prescription sleep medication, and an extra 30 minutes of sleep is quite noticeable to a sleep-deprived person.

View details on this melatonin sleep study.

Friday, May 19, 2006

CoQ10 Protects Against Alzheimer’s

Coenzyme Q10 protects against the neuro-toxic effects of amyloid beta peptides, a pathological characteristic of Alzheimer’s disease, according to researchers at the University of Coimbra in Portugal.

CoQ10 appears to counteract the alterations in brain mitochondria caused by amyloid beta peptides, and thus may help to avert the energy deficiency and oxidative stress that characterizes both diabetes and Alzheimer’s. Given the decline in CoQ10 with aging, the cumulative effects of oxidative stress, and the irreversibility of neural damage, especially in diabetics, the researchers strongly recommend the use of supplemental coenzyme Q10 for enhanced protection against Alzheimer’s disease.

Read details of this coenzyme Q10 Alzheimer's study.

Thursday, May 18, 2006

Omega-3 Fatty Acid Benefits Bone Health

Marine-derived omega-3 fatty acids, particularly DHA (docosahexaenoic acid), increase calcium absorption and deposition in bone, according to researchers in New Zealand.

Rats fed tuna oil (omega-3) absorbed significantly more calcium than the control group fed corn oil (omega-6). In addition, the rats fed fish or tuna oil excreted less calcium compared to the rats fed corn oil. Bone calcium content was significantly higher in the tuna oil group than in the corn oil group.

Marine-derived omega-3 fatty acid consumption helped to increase the bioavailability of dietary calcium and support its integration into bone tissue. These findings suggest that consumption of marine-derived omega-3 fatty acids, particularly DHA, may improve calcium absorption, optimize bone density, and offer protection against conditions such as osteoporosis.

View details on this omega-3 fish oil calcium bone health study.

Wednesday, May 17, 2006

Iron Deficiency a Factor in ADHD

The mean serum ferritin (iron) concentration was significantly lower in 53 French children with attention deficit-hyperactivity disorder (ADHD) than in 27 age-matched controls without ADHD. Low serum ferritin levels were correlated with more severe general ADHD symptoms.

Iron status should be measured in all children with ADHD. Those who are deficient, and possibly those whose ferritin levels are near the bottom of the normal range, should receive iron supplementation.

View details on this children's iron deficiency ADHD study.

Tuesday, May 16, 2006

Vitamin K Improves Artery Health

These results indicate that, in postmenopausal women taking calcium, zinc, magnesium, and vitamin D, supplementation with 1 mg/day of vitamin K1 for three years prevented a deterioration of the elastic properties of the carotid artery wall.

Adequate vitamin K status appears to be important not only for normal blood clotting function and bone metabolism, but also to maintain vascular health. Good food sources of vitamin K include green leafy vegetable, soybean oil, and olive oil.

View details on this Vitamin D, K artery health study

Monday, May 15, 2006

Vitamin D Decreases PSA Levels in Recurrent Prostate Cancer Patients

Previous studies have demonstrated anti-cancer and immune-enhancing properties of vitamin D, although most of the research has been observational or in laboratory animals.

Fifteen patients who had surgery or radiation therapy for prostate cancer, who were symptom-free but had experienced at least 3 consecutive increases in prostate-specific antigen (PSA) values over a minimum of 9 months, were treated with 2,000 IU /day of vitamin D3 (cholecalciferol).

The median PSA doubling time increased from 14.3 months prior to vitamin D treatment to 25 months after starting vitamin D; 14 of 15 patients had a prolongation of PSA doubling time. No side effects were reported.

Read details on this vitamin D PSA prostate cancer study.

Pomegranate Stops Progression of Prostate Cancer

Researchers have found that pomegranate fruit extract (PFE) inhibited prostate cancer cell growth and triggered cell death in a highly aggressive human prostate cancer cell line and caused similar effects when administered orally to rodents.

Researchers tested the oral administration of a human acceptable dose of pomegranate fruit extract on mice implanted with prostate cancer cells. In mice treated with pomegranate fruit extract there was a significant inhibition of tumor growth. In addition, pomegranate fruit also reduced secretion of prostate-specific antigen (PSA) in the serum of the animals.

View details on this pomegranate prostate cancer study.

Saturday, May 13, 2006

High Glycemic Diet Linked to Vision Loss

Scientists reported that consuming a "high glycemic-index" diet over a long period of time is associated with a higher risk of developing the early stages of a major eye disease--age-related macular degeneration, or AMD.

When ranked into three groups from highest to lowest in terms of dietary glycemic index, the participants who were ranked highest were over two times more likely to have macular pigment abnormalities as those ranked lowest. An abnormal level of macular pigment is an early indicator of macular degeneration. The macula is responsible for the maximum ability to receive light and distinguish images.

View details on this high glycemic diet age-related macular degeneration study.

Friday, May 12, 2006

Vitamin K Reduces Osteoarthritis Risk by 40%

Higher intake of vitamin K, found naturally in cabbage, spinach, cauliflower, and other green leafy vegetables, could reduce the risk of osteoarthritic knee problems by 40 per cent, says new research.

The researchers measured blood levels of phylloquinone, the main form of vitamin K, and correlated this with the occurrence of hand and knee osteoarthritis. The researchers concluded that their data support the link between vitamin K status and the risk of osteoarthritis, a disease that effects about seven million people in the UK alone are reported to have long-term health problems associated with arthritis.

View details on this vitamin K osteoarthritis study.

Thursday, May 11, 2006

Omega-3 Fish Oil Plus Low Calorie Diet Reduces Inflammation 90%

A low-calorie diet, rich in omega-3 rich fish oil could reduce the markers of inflammation by as much as 90 per cent, according to the results of an animal study. Chronic inflammation can lead to a range of inflammatory related disease, including cardiovascular, arthritis and autoimmune disease.

“The major findings of our present study are that dietary fish oil and/or a 40 per cent reduced food intake, ie. calorie-restriction, effectively suppressed age-related inflammatory process,” wrote the authors.

Read details of this omega-3 fish oil low calorie inflammation study.

Wednesday, May 10, 2006

CoQ10 May Protect Against Alzheimer’s

Increasing intake of coenzyme Q10 may ward off the threat of Alzheimer’s disease, if the results of an animal study can be applied to humans.

The body's manufacture of CoQ10 begins to drop after the age of about 20, leading to its investigation in age-related disease. The new study looked at the effect of CoQ10 supplementation on rats with forced brain impairment and oxidative damage.

Although the mechanism of Alzheimers is not clear, more support is gathering for the build-up of plaque from amyloid deposits. The deposits are associated with an increase in brain cell damage and death from oxidative stress. It is against the oxidative stress that CoQ10 appears to offer protection.

Read more on this coenzymeQ10 Alzheimer's study.

Tuesday, May 09, 2006

U.S. Farm Policy Contributes to Obesity and Disease

U.S. farm policy geared towards driving down prices for corn and soybeans is a significant contributor to the nation’s obesity epidemic, according to a report released by the Institute for Agriculture and Trade Policy (IATP).

Food Without Thought: How U.S. Farm Policy Contributes to Obesity, found that low prices for corn and soybeans over the last several decades have spurred investment in high fructose corn syrup (HFCS) and hydrogenated vegetable oils (Omega-6 transfats).

The historical ratio of Omega 3:Omega 6 in the human diet is 1:1. Deviation from this balance has been implicated in many disease conditions including cardiovascular, immune, and Alzheimer's disease. For each gram of Omega-6 oils you eat, it is recommended that you balance your intake with 1 gm of Omega-3 fish oil.

Read further details on this U.S. farm policy obesity disease article.

Monday, May 08, 2006

Inflammation Triples Risk of Colon Cancer

Researchers reporting in the February 2004 issue of the Journal of the American Medical Association find that people with the highest blood levels of C-reactive protein (a marker for systemic inflammation) are three times as likely to contract colon cancer as those in the lowest ranges.
Plasma CRP concentrations were higher among all colorectal cases combined than controls. The highest CRP concentration was found in people who subsequently developed colon cancer.

Neptune krill oil has demonstrated effectiveness in lowering CRP.

Read details of this inflammation c-reactive protein colon cancer study.

Sunday, May 07, 2006

Farmed Salmon Increases Inflammation; Wild Salmon Reduces Inflammation

Norwegian scientists measured the effects of different feeds on the nutritional composition of farm-raised salmon. Fish fed a diet high in vegetable oils have a much less favorable fatty acid composition than the salmon that consume a fish-oil rich diet. They also found that heart disease patients who ate the vegetable-oil fed salmon did not show the same cardiovascular improvements as patients who ate fish-oil fed salmon.

Typically farmed Salmon are fed corn products and byproducts - high in Omega-6 vegetable oil. Wild salmon eat krill, smaller fish, and algae, all rich sources of Omega-3 fatty acids - EPA and DHA. It is no wonder that wild salmon are beneficial (having anti-inflammatory properties) and farmed salmon is now found to not only not be beneficial (containing higher levels of antibiotics and pesticides), but they may be inflammatory.

Read details on this important farmed versus wild salmon omega 6 versus omega 3 study.

Saturday, May 06, 2006

Omega 3s Cut Risk of Second Heart Attack

A daily supplement of omega-3 fatty acids could reduce the risk of having a second heart attack, says a small clinical trial.

After four months of supplementation of placebo or omega-3, the researchers reported: “Our principle findings were that omega-3 fatty acids significantly decreased heart rate (HR) at rest, accelerated the return to a normal HR after standing and exercise, and increased HR variability in the high-frequency band.” After omega-3 supplementation the researchers reported a 19 per cent decrease in HR one minute after exercising. “The decrease in HR was accompanied by appropriate increases in stroke volume and ejection times,” said O'Keefe.

View further details on this omega-3 heart attack study.

Friday, May 05, 2006

Omega-3 Fish Oil Decreases, Omega-6 Corn Oil Increases Inflammation

A low-calorie diet, rich in Omega-3 rich fish oil could reduce the markers of inflammation by as much as 90 per cent, according to the results of an animal study. The new study, published in the journal Life Sciences, looked at the effects of fish oil and/or a calorie-restricted diet on various markers of inflammation for old and young female mice.
Mice eating the corn oil diet for 7 months had superoxides levels (a marker for inflammation) about 18 per cent higher than young mice. Young mice receiving the fish oil-containing diet had superoxides levels almost 60 per cent lower.

Read details on this omega-3 fish oil omega-6 corn oil inflammation study.

Thursday, May 04, 2006

Combination of Lycopene and Vitamin E Inhibits Growth of Prostate Tumors

BASF investigated how different doses of lycopene and vitamin E affect prostate tumor growth and whether a combination of lycopene and vitamin E exerts additional effects. Furthermore, the possibility to use PSA (prostate-specific antigen) levels in blood, which is an established clinical parameter for the disease, as a marker for tumor growth during lycopene and vitamin E intake was evaluated.

The combination of lycopene and vitamin E suppresses tumor growth in mice by 73 percent and increases survival time by 40 percent. Lycopene alone tends to inhibit tumor growth and to prolong survival time as well, but less effectively (53 percent and 19 percent, respectively). A phase-II clinical trial with prostate cancer patients is ongoing to evaluate the health benefits of lycopene and vitamin E in humans.

Read details on this lycopene vitamin E prostate cancer study.

Wednesday, May 03, 2006

Omega-3 Fatty Acids Equal or More Effective than NSAIDs

Estimates show that between 5 percent and 10 percent of the U.S. population uses non-steroidal anti-inflammatory drugs (NSAIDs) for pain relief. While NSAIDs are effective in treating both acute and chronic pain, they also may cause a myriad of complications, ranging from headaches and stomach ulcers to dizziness, constipation and diarrhea. A new study indicates that omega-3 fatty acids found in fish oil may be just as effective as NSAIDs in treating pain, without causing side effects.

In this study, scientists evaluated 250 patients who were taking NSAIDs for pain relief. The patients were asked to take 2,400 milligrams of omega-3 supplements per day for two weeks, and then to reduce the dosage to 1,200 milligrams daily.

59 percent of the patients reported they had discontinued using NSAIDs for pain control; 60 percent said their overall pain levels had improved; and 80 percent stated that they were satisfied with the improvement in pain. No adverse side effects were reported.

Read details on this omega-3 NSAID study.

Tuesday, May 02, 2006

D-Ribose Improves Pain And Quality Of Life In Fibromyalgia & Chronic Fatigue Patients

Jacob Teitelbaum, MD, and Valen Labs undertook a study to determine if D-Ribose, a simple sugar, can provide relief for the millions of patients afflicted with the diagnosis of fibromyalgia and/or chronic fatigue syndrome.

After the 28-day D-Ribose treatment period, a quality of life questionnaire was repeated, and 69-percent of the patients had significant improvement in their symptoms. They also averaged a 25-percent improvement in the quality of life scale.

Read details on this d-Ribose Fibromyalgia chronic fatigue study.

Monday, May 01, 2006

Omega-3 Fatty Acids Inhibit Growth of Liver Cancer Cells

Two new studies by a University of Pittsburgh research team suggest that omega-3 fatty acids--substances that are found in high concentrations in fish oils and certain seeds and nuts--significantly inhibit the growth of liver cancer cells.

In one study, the investigators treated the hepatocellular carcinoma cells with either the omega-3 fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) or the omega-6 fatty acid arachidonic acid (AA), for 12 to 48 hours. DHA and EPA treatment resulted in a dose-dependent inhibition of cell growth, whereas AA treatment exhibited no significant effect.

Read details on these 2 omega-3 fatty acid liver cancer studies.