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Hyaluronic Acid Center, Neptune Krill Oil & Rejuvenation Science for Doctors

Tuesday, February 28, 2006

Ribose Improves Ventilatory Efficiency in Congestive Heart Failure Patients

Ventilatory efficiency is recognized as an important predictor of survival and disease progression among patients with congestive heart failure (CHF). Thus, improving ventilatory efficiency in this population is of prime importance. A research report suggests that D-Ribose can play a significant role in this key pursuit.

It is well accepted that failing hearts are energy starved and lack sufficient energy for normal function. D-Ribose, a naturally occurring monosaccharide, has been shown to play a vital role in cellular energy creation.

Mark A. Munger, PharmD, Professor of Pharmacotherapy summarized the study "Beyond the previously known benefits of ribose in enhancing myocardial energy levels and improving diastolic function parameters following ischemia, this study demonstrated a benefit in ventilatory efficiency, one of the most powerful predictors of survival in congestive heart failure patients."

Read ribose ventalatory efficiency study details.

Monday, February 27, 2006

L-Carnitine Inhibits Gestational Diabetes

Intake of L-carnitine L-tartrate during pregnancy may thwart a sequence of reactions leading to gestational diabetes, according to a study published in Chemical Monthly.

Scientists at the University of Vienna noted deficiency of carnitine in pregnant women from the 12th week of gestation through delivery leads to down-regulation of expression of certain enzymes involved in fatty acid metabolism; low mRNA levels of these enzymes promotes an increase in free fatty acid levels conducive to insulin resistance. The researchers found supplementation with L-carnitine L-tartrate (as L-Carnipure®, from Lonza) increased relative mRNA levels of these enzymes in pregnant women.

Read conclusions on this carnitine gestational diabetes study.

Sunday, February 26, 2006

Low CoQ10 Levels Associated with 790% Increased Risk of Melanoma Metastasis

117 consecutive melanoma patients were enrolled in this study. Plasma coenzyme Q10 (CoQ10) levels were measured upon enrollment.

Researchers found that CoQ10 levels were significantly lower in melanoma patients than in control subjects. Further, it was noted that for melanoma patients with CoQ10 blood levels of less than 0.6 mg per liter, risk of developing metastatic disease increased by 790 percent, compared to those melanoma patients with blood levels of 0.6 mg per liter or higher. In addition, melanoma patients with higher blood levels were noted to have a metastasis-free interval that was almost double compared to patients with lower levels.

Read more on this important CoenzymeQ10 cancer study.

Saturday, February 25, 2006

Berries Inhibit Oxidative and DNA Damage

Blackcurrants are small, juicy, dark purple berries that are high in vitamin C and have a slightly bitter taste. Boysenberries are genetically similar to blackcurrants. Both berry types are rich in anthocyanins, potent disease-fighting antioxidants. Fruits high in anthocyanins tend to have deep red or purple hues.

In a recent study, researchers discovered that both blackcurrant and boysenberry extracts helped combat oxidative stress and DNA damage, two processes that contribute to Alzheimer's disease, cancer, and aging. Although the study results are preliminary and need to be confirmed with further research, antioxidant-rich fruits remain a smart food choice. Eat a colorful assortment of different fruits and vegetables to get a healthy mix of disease-fighting compounds every day.

View berry oxidative and DNA damage study details.

Friday, February 24, 2006

Folate, Vitamin B6 Counteract Colorectal Cancer

Higher dietary intake of folate and vitamin B6 may reduce the risk of colorectal cancer in women, according to a study published in the American Journal of Epidemiology.

Researchers looked for a relationship between intakes of folate and vitamin B6 and colorectal cancer risk among 37,916 women. During follow-up, 220 colorectal adenocarcinoma cases were documented. Dietary intakes of folate and vitamin B6 were significantly inversely associated with colorectal cancer risk among women who were not taking supplements containing folate and vitamin B6.

Read details of this folate vitamin B6 colorectal cancer study.

Thursday, February 23, 2006

Folate Intake Predicts Homocysteine Level and Fracture Risk

In a study conducted by researchers from Italy, incident osteoporotic fractures were assessed for a mean of four years in 702 Italian test subjects aged 65 to 94 years. The researchers examined the relationship between plasma homocysteine, serum folate and serum vitamin B12, and risk of fracture.

Participants in the lowest serum folate quartile had a greater risk of fracture than individuals in higher quartiles. The researchers concluded folate status is responsible for the association between homocysteine and risk of osteoporotic fracture in elderly persons.

Read details on this folate homocysteine bone fracture study.

Wednesday, February 22, 2006

DHEA(S) Supplementation Reduces Age-Related Left Ventricular Stiffness and Fibrosis

The adrenal steroid hormone dehydroepiandrosterone (DHEA) and its sulfated derivative [DHEA(S)] have been extensively studied for their potential anti-aging effects. Researchers at the University of Arizona wrote, "Associated with aging, DHEA levels decline in humans, whereas other adrenal hormones remain unchanged, suggesting that DHEA may be important in the aging process.

Treatment with DHEA(S) decreased left ventricular stiffness in older mice and increased left ventricular stiffness in young mice.

The researchers concluded "exogenous DHEA(S) supplementation is capable of reversing the left ventricular stiffness and fibrosis that accompanies aging, with a paradoxical increased ventricular stiffness in young mice."

View further details on this DHEA heart study.

Tuesday, February 21, 2006

Melatonin Decreases Progression of Age-Related Macular Degeneration

Researchers investigated the effect of melatonin on age-related macular degeneration (ARMD). They decided to undertake the study because melatonin has been shown to control eye pigmentation and thereby regulate the amount of light reaching the photoreceptors. In addition, melatonin scavenges free radicals and protects retinal pigment epithelium cells from oxidative damage. Consequently, the age-related decrease in melatonin could be an important factor in the dysfunction in retinal pigment epithelium cells known to cause the initiation of ARMD.

“We conclude that the daily use of 3 mg melatonin seems to protect the retina and to delay macular degeneration,” the study authors wrote.

Read the details of this melatonin - age related macular degeneration study.

Monday, February 20, 2006

Vitamin E Helps Prevent Cataracts

A new study has found yet another reason for people to start supplementing vitamin E in their diet: to help prevent cataracts. As the most common cause of blindness worldwide, cataracts increase with age from less than five percent in persons under 65 to approximately half of those 75 years of age and older. Cataracts refer to lens cloudiness that gradually interferes with vision and leads gradually to a loss of vision.

Despite not examining vitamin E amounts, the researchers concluded that “long-term use of vitamin E supplements and higher riboflavin and/or thiamin intake may reduce the progression of age-related lens opacification.”

Read more about this vitamin E cataract study.

Sunday, February 19, 2006

Betaine Reduces Homocysteine Levels

In an article published in the January 2006 edition of the journal Nutrition, researchers from Finland reported on a small study examining the effects of betaine (trimethylglycine) and homocysteine metabolism.

It was concluded that a single dose of orally administered betaine had an acute and dose-dependent effect that resulted in lower homocysteine concentrations within two hours in healthy subjects.

Read details on this betaine - homocystein study.

Saturday, February 18, 2006

Resveratrol Reduces Flu Mortality by 60%

An Italian study found red wine is not only heart healthy, but may help fight flu as well. Scientists from Italy's Higher Health Institute, Rome University and the National Research Council discovered that resveratrol a compound in red wine that stops the flu virus from mutating.

"This discovery is very important because it increases the possibility of combating the virus and has proved effective against all different types of flu," the investigators said. "That resveratrol acts by inhibiting a cellular, rather than a viral, function suggests that it could be a particularly valuable anti-influenza drug."

Read more about this resveratrol flu study.

Lycopene Reduces Blood Pressure

Clinical research conducted at Ben-Gurion University, Israel shows that lycopene complex, a tomato extract, reduces blood pressure in patients with mild to moderate hypertension.

In a random double-blind, placebo-controlled crossover trial, Dr. Esther Paran, M.D., evaluated the effect of tomato extract on blood pressure, endothelial function and plasma lycopene levels in grade I hypertensive patients.

“Eating a diet rich in tomato products and other antioxidant-containing fruits and vegetables is certainly a smart move,” said Dr. Paran, “But, a person would need to consume about five tomatoes to get the nutrients in one tomato extract capsule.”

Read more on this lycopene - blood pressure study.

Friday, February 17, 2006

Resveratrol Extends Lifespan by 50%

A glass of red wine may not only compliment your meal, it may also buy you some time to enjoy more out of life. A new study shows resveratrol, a component of red wine, which has previously shown to prolong the life of worms and fruit flies, may extend the lifespan of vertebrate animals like fish and possibly humans.

Researchers found fish fed the lower dose of resveratrol lived an average of 33% longer than fish fed their normal diets, while those fed the higher dose of the red wine ingredient lived more than 50% longer.

Read more details of this resveratrol life extension study.

Thursday, February 16, 2006

Whole Grains and Low-Glycemic Food Reduce Inflammation

Whole grains and a low-glycemic index diet may reduce systemic inflammation among women with type 2 diabetes, according to a study published in the February 2006 issue of Diabetes Care.

Concentrations of CRP and TNF-R2 were 18% and 8% lower in the highest quintile of cereal fiber as compared with the lowest quintile. Dietary glycemic index was positively associated with CRP and TNF-R2 levels. The concentrations of CRP and TNF-R2 were 32% and 11% higher, respectively, in the highest quintile of dietary glycemic index as compared with the lowest quintile.

Read further low-glycemic diet - inflammation study. Stevia is a 0-glycemic sweetener.

Black Cohosh, St. John's Wort Combo May Benefit Menopausal Women

German researchers found a fixed combination of St. John's wort and black cohosh was able to help alleviate psychological and physical complaints associated with menopause.

After the treatment period, the mean Menopause Rating Scale score decreased 50 percent in the treatment group and 19.6 percent in the placebo group. Similarly, the Hamilton Depression Rating Scale total score decreased 41.8 percent in the treatment group and 12.7 percent in the placebo group.

View more details on the Black Cohosh - St. John's Wort Menopause study.

Tuesday, February 14, 2006

Green Tea Associated with Reduced Cognitive Impairment

The objective was to examine the association between green tea consumption and cognitive function in humans.

High consumption of green tea at two or more cups per day by the top one-third of participants was associated with less than half the incidence of cognitive impairment, including severe cognitive impairment, than that found among participants whose intake was in lowest third at three or fewer cups per week. Participants whose tea consumption was in the middle third with a 1 cup per day habit, experienced a 38 percent reduction. No significant relationship between black tea or coffee consumption and cognitive impairment was observed.

The authors suggest that the lower prevalence of dementia and Alzheimer's disease in Japan could be explained by the green tea consumed by this population.

Read more about this green tea dementia study.

Monday, February 13, 2006

Selenium, Carotenoids Lower Mortality in Older Women

Intake of selenium and carotenoids such as lutein, zeaxanthin, lycopene and beta carotene may thwart inflammation-driven diseases leading to fatality in the aged.

Researchers followed elderly women enrolled in the Women's Health and Aging Studies I and II. Of those women followed, 14.1 percent died. The five major causes of death were heart disease (32.6 percent), cancer (18.0 percent), stroke (9.0 percent), infection (6.7 percent), and chronic obstructive pulmonary disease (5.6 percent).

The researchers discovered higher blood levels of selenium and total carotenoids were associated with a lower risk of mortality, and concluded higher levels of these compounds may lower risk of mortality.

Read more information on this women's aging study.

Sunday, February 12, 2006

Red Wine Consumption Reduces Inflammation

Adding Sicilian red wine to the diet of 48 non-drinkers for four weeks decreased levels of inflammatory and oxidative-stress-related biomarkers, and increased plasma antioxidant levels.

At the end of the red wine intake period, the researchers found significantly decreased levels of C-reactive protein, oxidized low-density lipoprotein (LDL) cholesterol and fibrinogen, as well as a lower LDL/high-density lipoprotein (HDL) ratio. In addition, red wine consumption increased total plasma antioxidant capacity and total HDL levels, suggesting moderate consumption of red wine in adults is a positive component of the Mediterranean diet.

Read more about resveratrol, the active constituent of red wine.

Read more about this red wine inflammation study here.

Saturday, February 11, 2006

Omega-3 fatty acids reduce risk of dry eye syndrome; Omega-6 fatty acids increase risk

In a study from Harvard Medical School in Boston, Massachusetts, and Brigham and Women's Hospital, women with a higher dietary intake of omega-3 fatty acids were at decreased risk of developing dry eye syndrome (DES).
Women who ate the most Omega-3 fatty acids lowered their chances of dry eye syndrome by as much as 68 percent. Conversely, those who ate a higher ratio of omega-6 fats versus omega-3 fats doubled their odds of dry eye syndrome. Although this is the first study that has evaluated this relationship, and confirmation from other studies is needed, the findings are consistent with clinical observations and postulated biological mechanisms," the authors write.

Read details on this omega-3 dry eye study.

Friday, February 10, 2006

Resveratrol Protects Against Breast Cancer

Researchers report in the International Journal of Cancer that resveratrol, a component of red wine, inhibited the development of mammary tumors in mice and reduced the mean number and size of tumors in the animals. Past studies have indicated that resveratrol may possess anti-cancer activity on the basis of its in vitro effects on tumor cells and its effects in vivo on rodents transplanted with tumors or treated with carcinogens.

In the current study, the Italian researchers investigated resveratrol’s effects on the development of mammary tumors appearing in an experimental model of mice and breast cancer. Resveratrol supplementation delayed the development of spontaneous mammary tumors, reduced the mean number and size of mammary tumors and diminished the number of lung metastases in the mice.

Read more about resveratrol here.

Thursday, February 09, 2006

Cranberry Compounds Block Cancer

New data shows that proanthocyanidins, or PACs, found in cranberries inhibit the growth of lung tumors and colon and leukemia cells. "While previous studies have shown that cranberry extracts inhibit the proliferation of cancer cells, this is the first study to confirm that it's the cranberry PACs that are the active components," said Catherine C. Neto, Ph.D.
"In light of our findings and previously published studies, cranberries may inhibit the spread of cancer in a variety of ways," said Neto.

Read more on this cranberry cancer study.

Wednesday, February 08, 2006

Lower Colon Cancer Risk for Women with High Magnesium Intake

Drs Aaron R Folson and Ching-Ping Hong at the University of Minnesota in Minneapolis have confirmed an association between diets that contain higher amounts of magnesium and a reduced risk of colon cancer among women.

Foods high in magnesium such as vegetables and grains have already been shown to be protective against colorectal cancer because of their fiber content and beneficial micronutrients. Magnesium assists in calcium absorption and calcium has shown to be protective against colon cancer in other studies. Therefore, it was not clear after this 15-year study whether magnesium alone or other aspects of a healthy diet are responsible for the effects revealed in this study.

Read more about this Magnesium Cancer study.

Stevia Suppresses Inflammation

Stevioside, a non-caloric sweetener isolated from Stevia rebaudiana Bertoni, may suppress harmful inflammation, according to a study published in the February 2006 Journal of Agricultural and Food Chemistry.

Researchers from Mahidol University in Bangkok, Thailand induced inflammation in a human leukemia cell line and treated the cells with stevioside. At 1 mM, stevioside significantly inhibited LPS-induced release of the inflammatory cytokines tumor necrosis factor alpha and interleukin 1-beta without exerting any direct toxic effects. The researchers concluded the data suggest stevioside attenuates synthesis of inflammatory mediators in LPS-stimulated THP-1 cells.

Read Stevia Study parameters.

Tuesday, February 07, 2006

Ginkgo Aids MS Patients

Extract of Ginkgo biloba may improve functionality among multiple sclerosis (MS) patients, according to a clinical trial published January 2006 in EXPLORE: The Journal of Science and Healing.

Substantially more individuals given ginkgo than those given placebo showed significant improvement on four or more measures of fatigue, symptom severity and functional performance. It also showed that no adverse events or side effects were reported and that ginkgo exerted modest beneficial effects on select functional measures (eg, fatigue) among some individuals with MS.

Read more about this ginkgo biloba study on MS patients.

Monday, February 06, 2006

Milk Thistle Protects Against Skin Cancer

In a study published in the January 2005 issue of the International Journal of Oncology, researchers concluded that Silymarin, a plant flavonoid isolated from the seeds of milk thistle, shows promise in protecting the skin against damage from ultraviolet radiation.

“The available experimental information suggests that Silymarin is a promising chemopreventive and pharmacologically safe agent, which can be exploited or tested against skin cancer in the human system,” the researchers concluded. “Moreover, Silymarin may favorably supplement sunscreen protection and provide additional anti-photocarcinogenic protection.”

Read more on this milk thistle cancer study.

Sunday, February 05, 2006

Omega-6 Fatty Acids Fuel Prostate Cancer Growth

A study published in the February 1 2006 issue of the journal Cancer Research reported that the addition of an omega-6 fatty acid to cultured prostate cancer cells doubled their growth rate compared to untreated prostate cancer cells. Omega-6 fatty acids are found in vegetable oils, such as corn and safflower oil, margarine, salad dressings, and prepared foods such as baked and frozen goods.

"After we added omega-6 fatty acids to the growth medium in the dish, we observed that tumors grew twice as fast as those without omega-6," Dr Fulford-Hughes explained. "Investigating the reasons for this rapid growth, we discovered that the omega-6 was turning on a dozen inflammatory genes that are known to be important in cancer."

Read more on this important Omega-6 Cancer study.

Saturday, February 04, 2006

Pomegranate Juice Beneficial for Coronary Heart Disease

Researchers investigated whether daily consumption of pomegranate juice for three months would affect myocardial perfusion in 45 patients who had coronary heart disease (CHD) and myocardial ischemia in a randomized, placebo-controlled, double-blind study.

According to the study findings, blood flow to the heart improved by 17% in the pomegranate group and declined by 18% in the placebo group. Researchers pointed out that the benefits were realized without any negative effects on lipids, blood glucose, hemoglobin A1c, body weight or blood pressure.

Read more on this Pomegranate Juice study.

Friday, February 03, 2006

Pine Tree Bark Reduces Arthritis Pain by Inhibiting COX-II

A study published last month demonstrates the natural pain reduction properties of pine bark extract for COX inhibition. Patients who supplemented with pine tree bark extract known as Pycnogenol® demonstrated a decrease in pain and inflammation by non-selectively lowering cyclooxygenase activity, also known as COX-1 and COX-2.
According to a separate study to be released later this year, results showed Pycnogenol reduced symptoms of knee osteoarthritis (OA). The double-blind, randomized, placebo-controlled study of 35 OA patients who supplemented for 60-90 days with Pycnogenol demonstrated significantly reduced self-reported pain, stiffness and increased physical function compared to placebo treated patients.

Read more on this Pycnogenol-Arthritis Pain Relief study.

Thursday, February 02, 2006

CoenzymeQ10 Safe at Doses up to 900 mg/day

Kaneka Corporation of Japan recently conducted a safety assessment of CoenzymeQ10 on Japanese healthy subjects with a double blind, randomized placebo-controlled trial in Japan.

Coenzyme Q10 in softgel form was taken for four weeks at doses of 300mg, 600 mg, and 900mg per day. These results showed that CoenzymeQ10 in healthy subjects was well tolerated in dosages up to 900mg per day.

Read CoQ10 Safety study details.

Wednesday, February 01, 2006

Copper Deficiency Associated with Alzheimer's Disease

In this study, investigators looked into the ability of copper to stabilize cognitive decline in patients suffering from Alzheimer's disease.

Over 87% of the subjects exhibited a negative correlation between plasma copper levels and cognitive decline. Those with medium plasma copper levels made fewer mistakes in the memory test compared to those with low plasma copper levels. Researchers claim this finding supports the hypothesis of a mild copper deficiency in most Alzheimer patients. As such, they believe supplementation with copper might be necessary to stave off cognitive decline in Alzheimer's patients.

Read more on this relationship between copper levels and Alzheimer's disease.