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AHCC® - Comparison to MGN3 and PeakImmune4


  • An independent scientific comparison was performed in order to investigate the difference between the nutritional supplement MGN-3 distributed by Lane Labs, and AHCC® manufactured by Amino-Up Chemical Company in Japan and distributed under the brands ImmPower and Source Naturals. This comparison disproved the claim that MGN-3 is a more powerful immune supporting supplement.

  • Since PeakImmune4 is said by the manufacturer Daiwa Pharmaceutical Co., Ltd. to be identical to MGN-3, AHCC would be 160% more effective than PeakImmune4 also.

  • More information on AHCC.

January 31, 2001

Re: Independent comparison of MGN-3 and AHCC®

An independent comparison of MGN-3 and AHCC® has disproved the claim that MGN-3 is a more powerful Immune supporting supplement. On the measure of Natural Killer (NK) cell function, the primary focus of the MNG-3 claims, an equal amount of AHCC was found to increase NK cell cytotoxicity on average by 24% more than MGN-3

The study was undertaken at our request by Dr. M. Hosokawa of Hokkaido University, Division of Cancer Pathobiology, Institute for Genetic Medicine, in Sapporo, Japan. Dr. Hosokawa is extensively published in the subjects of cancer biology and immunotherapy. He obtained commercially available quantities of MGN-3 and AHCC from Emerson Ecologics, Inc., a U.S distributor of both products.

Healthy 8-week old male BALB/C mice were treated with equal amounts of AHCC or MGN-3 1g/kg bw/day, orally administered for 7 days. Control mice were treated with tap water at the same volume. At day 7, the mice were sacrificed, spleens were removed and NK cells were isolated. Using the PKH67 Green Flourescent Cell Linker Kit (SIGMA, St. Louis, MO) , NK cell cytotoxicity was measured against PKH67 stained Yac-1 target cells, at Effector: Target ratios of 100:1, 50:1, 25:1, 12.5:1.

Results were as follows:

Percent NK cell Cytotoxicity     

                    --------- Treatment Groups ----------
                     Control       MGN-3         AHCC        Increase vs MGN-3
Effector: Target Ratio
100:1               20%           29%            42%                45%
50:1                 10%           15%            17%                13%
25:1                  8%            12%            13%                8%
12.5:1              12%           12%            14%               17%

Total Enhancement                              69%               90%

Total Enhancement AHCC vs MGN-3 = 160%

The claims by Mamdooh Ghomeum, the patent holder of MGN-3 and Andy Lane of Lane Labs in sales literature, that “MGN-3 has proven to be six times more effective that AHCC…” have never been substantiated - either by third party research, or by Dr. Ghoneum’s own research, which is by nature biased.

This independent study, though limited in scope should be sufficient to show that the MGN-3 claims are false. The best comparison of the two products is found by reviewing the published research on both. Almost all the research on MGN-3 has been conducted by Dr. Ghoneum, whose financial interest in the sale of that product should raise questions. In contrast, there is a substantial body of research on AHCC, done by many different groups of independent doctors, pre-clinical animal studies, and human clinical trials illustrating mechanisms of action, enhancement of immune system function and improvement in clinical status.

Maypro Industries, Inc. 2700 Westchester Avenue, Purchase NY 10577   Tel: 914. 251.0701   Fax: 914.251.0746

  • More information on AHCC.

  • Reprinted with exclusive permission of Source Naturals, Inc.

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Featured Products
 
AHCC book FREE UPON REQUEST with orders of 2 or more bottles of AHCC - just note in comments section of your order.  Limit 1 book per customer please.
 
  ImmPower AHCC  30 capsules
MSRP:
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